UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 43 / No. 3 / Published : 2010-07

Order : 2, and page :113 - 116

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Original Article :

Anti-inflammation effects of sardinella longicep oils against paw oedema on rattus novergicus induced by 1% carrageenan

Author :

  1. Rima Parwati Sari*1
  2. Yenny Sugiharto*2
  1. Department of Oral Biology, Faculty of Dentistry, Universitas Hang Tuah
  2. Department of Oral Biology, Faculty of Dentistry, Universitas Hang Tuah

Abstract :

Background: People usually used NSAID such as aspirin in chronic inflammation treatment. However, using NSAID at long term therapy will cause many effecst such as vomit and nausea. Sardinella longiceps oil, on the other side, is reported as an alternative treatment for anti-inflammation since it is natural and also containes with eicosapentaenoid acid (EPA) and decohexaenoic acid (DHA). Thus, it may reduce oedema paw. Purpose: The aim of this study is to know the anti-inflammation effects of Sardinella longiceps oil against oedema paw of Wistar rats induced by 1% carrageenan. Methods: The samples of this research were 32 Wistar rats whih were then divided into four groups. Group 1, the rats were given aquadest; group 2, the rats were given aspirin; group 3, the rats were given Sardinella longiceps oil 1 ml; group 4, the rats were given 1.5 ml Sardinella longiceps oil. All of the rats, nevertheless, were given intraplantar induction of 1% carrageenan into the paw of rats to make the inflammation condition, first. Results: All data were tested with normality test. The normal data were then analyzed with Homogenity of Variances and also ANOVA test which result showed significant differences. The data which showed significant differences were tested again with LSD test. The result then showed that group given 1 ml Sardinella longiceps oil and group given 1.5 ml Sardinella longiceps oil had no significant differences from group given aspirin, but there were significant differences between group given 1 ml Sardinella longiceps oil and group given 1.5 ml Sardinella longiceps oil, and also between group given 1.5 ml Sardinella longiceps oil and group given aquadest. Conclusion: Sardinella longiceps oil could reduce oedema paw in Wistar rats induced with 1% carrageenan.

Keyword :

Sardinella longiceps oil, aspirin, 1% carrageenan, anti-inflammation,


References :

Guyton AC,(2008) Buku ajar fisiologi kedokteran Jakarta : EGC





Archive Article

Cover Media Content

Volume : 43 / No. : 3 / Pub. : 2010-09
  1. Computer Aided Diagnosis For Osteoporosis Based On Trabecular Bone Analysis Using Panoramic Radiographs
  2. Anti-inflammation Effects Of Sardinella Longicep Oils Against Paw Oedema On Rattus Novergicus Induced By 1% Carrageenan
  3. The Correlation Between Immunoexpression Of Estrogen Receptor And The Severity Of Periodontal Disease
  4. The Effectiveness Of Sharp End And Rounded End Bristle Toothbrush
  5. Contact Hypersensitivity After Using  Tongue Piercing
  6. Cervical End Preparation Design Of Collarless Metal Ceramic Crown To The Decrease Of Bacterium Colony Number
  7. Treatment Of Sharp Mandibular Processus Alveolaris With Hybrid Prosthesis
  8. The Combination Of Miacalcic, Calcium Lactate, And Vitamin C As Post-extraction Alveolar Bone Resorption Inhibitor
  9. The Molecular Pheomena Of  The Blaz Genes   Forming Beta-lactamase Enzymes Structure In Staphylococcus Aureus Resistant To Beta-lactam Antibiotics (ampicillin)
  10. Management Of Idiopathic Alveolar Bone Necrosis Associated With Oroantral Fistula After Upper Left  First Molar Extraction
  11. Indirect Veneer Treatment Of Anterior Maxillary Teeth With Enamel Hypoplasia

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