UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 39 / No. 3 / Published : 2006-07

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Original Article :

Anticarcinogenesis effect of gynura procumbens (lour) merr on tongue carcinogenesis in 4nqo-induced rat

Author :

  1. Agustina*1
  2. Wasito*2
  3. Haryana*3
  4. Supartinah*4
  1. Oral Medicine Department, Faculty of Dentistry, Gadjah Mada University
  2. Pathology Department, Faculty of Veterinary Medicine, Gadjah Mada University
  3. Histology and Molecular Biology Department, Faculty of Medicine, Gadjah Mada University
  4. Pedodontics Department, Faculty of Dentistry, Gadjah Mada University Jogjakarta - Indonesia

Abstract :

In Indonesia Gynura procumbens (Lour) Merr leaves have been long used as various cancers medication. Many in vitro and in vivo studies have demonstrated anticarcinogenesis of ethanol extract of Gynura procumbens leaves. The aim of this study was to investigate the anticarcinogenesis of the ethanol extract of Gynura procumbens leaves on 4 nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis. Fifty six 4 week old male Sprague Dawley rats were used in this study and divided into 7 groups. Group 1, 2 and 3 were lingually induced by 4NQO for 8 weeks. In groups 2 and 3 the extract was given simultaneously with or after 4NQO induction finished, each for 10 weeks and 26 weeks, respectively. Groups 4, 5 and 6 were induced by 4NQO for 16 weeks. However, in groups 5 and 6 the extract was given as well simultaneously with or after the 4NQO induction, each for 18 weeks, respectively. Group 7 served as the as untreated control group. The results from microscopical assessment showed that tongue squamous cell carcinomas (SCC) developed in 100% (3/3) of group 1. However, only 33.3% (2/6) and 25% (2/8) of rats in groups 2 and 3, respectively demonstrated tongue SCC. Among groups 4, 5 and 6, no significant difference of tongue SCC incidence was observed. From these results it is apparent that the ethanol extract of Gynura procumbens leaves could inhibit the progression of 4NQOinduced rat tongue carcinogenesis in the initiation phase.

Keyword :

Gynura procumbens, 4NQO, rat, tongue carcinogenesis ,


References :

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Boey,(2003) The pathology of oral cancer - : Pathology

McDonald,(2003) The pathology of oral cancer - : Pathology

Sajid,(1987) Frequency of the oral cancer at the Dental Clinic of the Dr. Sardjito Hospital during 3 years Singapore : Scientific Abstracts-Free Paper Session on First International Congress on Oral Cancer and Jaw tumours

Sudarto,(1991) Daya antibakteri minyak atsiri daun dewa (Gynura procumbens (Lour) Merr Jogjakarta : laporan Penelitian Fakultas Farmasi UGM

Sugiyanto,(1993) Efek penghambatan karsinogenisitas benzo(a)piren oleh preparat tradisional tanaman Gynura sp. dan identifikasi awal senyawa yang berkhasiat Jogjakarta : Fakultas Farmasi UGM

Sudarto,(1993) Efek penghambatan karsinogenisitas benzo(a)piren oleh preparat tradisional tanaman Gynura sp. dan identifikasi awal senyawa yang berkhasiat Jogjakarta : Fakultas Farmasi UGM

Meiyanto,(1993) Efek peng



Archive Article

Cover Media Content

Volume : 39 / No. : 3 / Pub. : 2006-09
  1. Periodontal Tissue Damage In Smokers
  2. Management Of Oral Focal Infection In Patients With Asthmatic Symptoms
  3. The Copper Concentration Variation To Physical Properties Of High Copper Amalgam Alloy
  4. Is It Possible To Distinguish The Understanding Of Denture Adhesive Between Japanese Dental Students And Indonesian Peers By A Questionnaire?
  5. Mandible Vertical Height Correction Using Lingual Bone-split Pedicle Onlay Graft Technique
  6. Facial, Upper Facial, And Orbital Index In Batak, Klaten, And Flores Students Of Jember University
  7. Effects Of Orthodontic Forces On Pulp Tissue
  8. The Effect Of Humidity On Peak Value Of Hema Carbonyl Absorbance Band
  9. Anticarcinogenesis Effect Of Gynura Procumbens (lour) Merr On Tongue Carcinogenesis In 4nqo-induced Rat
  10. Clinical Evaluation In Periodontitis Patient After Curettage

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