UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 42 / No. 1 / Published : 2009-01

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Original Article :

Antioxidant effect of minocycline in gingival epithelium induced toxin actinobacillus actinomycetemcomitans serotype b

Author :

  1. Ernie Maduratna Setiawati*1
  1. Department of Periodontology
    Faculty of Dentistry Airlangga University
    Surabaya - Indonesia

Abstract :

Background: Actinobacillus actinomycetemcomitans (Aa) serotype b has been associated with aggressive periodontitis. Gingival epithelial cell exquisitely sensitive to the toxin so that may lead to the epithel protective barrier disruption. Experimental models show that minocycline is not related to it’s antimicrobial effect and protects against apoptosis neuron cell of a number experimental models of brain injury and Parkinson’s disease. Purpose: In this study, we examined antioxidant effect of minocycline to inhibit apoptosis of gingival epithelium induced crude toxin bacteria Aa serotype b in mice. Methods: Thirty adult mice strain Swiss Webster (balb C) were divided randomly into three groups: control group (group A), toxin group (group B) and toxin and minocycline group (group C). The mice were sacrificed at 24 hours after application, and then the tissue sections of gingival epithelium were stained with tunnel assay and imunohistochemistry. Result: Treatment with these toxin induced apoptosis of gingival epithelium was associated with DNA fragmentation and reduced gluthatione (GSH). Minocycline 100nM significantly increased GSH and reduced apoptosis (p

Keyword :

minocycline, GSH, apoptosis, Aa serotype b crude toxin ,


References :





Archive Article

Cover Media Content

Volume : 42 / No. : 1 / Pub. : 2009-03
  1. The Transformation Of Ordinal Scale For Parametric Statistic Analysis On Dental Health Questionnaire
  2. Chronic Gingivitis And Aphthous Stomatitis Relationship Hypothesis: A Neuroimmunobiological Approach
  3. The Role Of Microendodontics In Treating Mandibular Second Molar With Five Canals
  4. Toxicity Testing Of Chitosan From Tiger Prawn Shell Waste On Cell Culture
  5. The Effect Of Toothpaste Containing Kayu Sugi Extract On Plaque Formation
  6. Simple Replantation Protocol To Avoid Ankylosis In Teeth Intended For Orthodontic Treatment
  7. Treatment Of Temporomandibular Dissorder’s Using Occlusal Splint
  8. Inhibitory Effect Of N-hexane : Ethyl Acetate Fraction From Artemisia Vulgaris L. On Cell Culture Of Epithelial Carcinoma Of The Mouth
  9. Antioxidant Effect Of Minocycline In Gingival Epithelium Induced Toxin Actinobacillus Actinomycetemcomitans Serotype B
  10. Esthetic Rehabilitation Of Crowded And Protruded Anterior Dentition
  11. Patient Safety Oriented To Improve Patient Retention In Oral Health Services

Information DENTJ