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Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 47 / No. 1 / Published : 2014-03

Order : 1, and page :1 - 6

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Original Article :

Combination of aloe vera and xenograft induction on decreasing of nf-kb of tooth extraction socket preservation in cavia cobaya

Author :

  1. Utari Kresnoadi *1
  1. Dosen Fakultas Kedokteran Gigi

Abstract :

Background: Tooth extraction can naturally cause inflammation triggering osteoclast proliferation and alveolar bone resorption. Preservation of the tooth extraction sockets is needed for patients in order to reduce alveolar bone resorption risks. Aloe vera is known to have anthraquinones components, namely Aloin, Aloe emedin, and barbaloin, considered as anti-inflammation. Therefore, to overcome the inflammation, the role of NF-κβ is very significant to decrease nuclear factor kappa β (NF-κβ). As a result, inflammation risks will be decreased.  Purpose: The study was aimed to determine whether the induction of the combination of Aloe vera and XCB into tooth extraction sockets can reduce inflammation by reducing NF-κβ expression, osteoclasts and osteoblasts. Methods: Forty-eight Cavia cobaya were divided into eight groups, each of which consisted of six animals. The mandibular incisors of those Cavia cobaya were extracted and induced with either PEG, XCB, Aloe vera, or the combination of Aloe vera + XCB. Those animals were sacrificed on day 7 and day 30 after the extraction. Then immunohistochemical and histopathology examinations were conducted to observe NF-κβ expression, osteoblasts and osteoclasts. Results: It was known that in group induced with the combination of Aloe vera and xenograft concelous bovine, the growth of osteoblasts was high, while NF-κβ expression and osteoclasts reduced. Conclusion: It can be concluded that the induction of the combination of Aloe vera and XCB into the tooth extraction sockets can reduce NF-κβ expression and osteoclast, as a result, alveolar bone resorption risks decrease, and osteoblast increase.  

Keyword :

Aloe vera, NF-κβ, tooth extraction socket, xenograft,


References :

Lieberman JR,(2005) Bone regeneration and repair Totowa : Humana Press





Archive Article

Cover Media Content

Volume : 47 / No. : 1 / Pub. : 2014-03
  1. Combination Of Aloe Vera And Xenograft Induction On Decreasing Of Nf-kb Of Tooth Extraction Socket Preservation In Cavia Cobaya
  2. Role Of Hsp60, Cd-8 And Ifn-γ On The Imunopatobiogenesis Of Periapical Granuloma On Dental Caries
  3. The Expressions Of Nf-κβ And Tgfβ-1 On Odontoblast-like Cells Of Human Dental Pulp Injected With Propolis Extracts
  4. Induction Of Spirulina Chitosan Gel Into Cavia Cobaya Socket Toward Healing Process Post Extraction
  5. Alkaline Phosphatase Expression During Relapse After Orthodontic Tooth Movement
  6. Antimicrobial Proteins Of Snail Mucus (achatina Fulica) Against Streptococcus Mutans And Aggregatibacter Actinomycetemcomitans
  7. The Effect Of Immersion In Soda On Nano Hybrid Composite Resin Discoloration
  8. The Role Of Heat Shock Protein 27 (hsp 27) As Inhibitor Apoptosis In Hypoxic Conditions Of Bone Marrow Stem Cell Culture
  9. The Sensitivity And Specificity Test Of Pediatric Caries Predictor Software
  10. The Effect Of Position And Volumetric Fraction Polyethylene Fiber On The Flexural Strength Of Fiber Reinforced Composite
  11. Oral Hygiene And Number Of Oral Mucosal Lesion Correlate With Oral Health-related Quality Of Life In Elderly Communities Of Yogyakarta City

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