UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 45 / No. 2 / Published : 2012-06

Order : 9, and page :102 - 106

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Original Article :

Deoxypyridinoline level in gingival crevicular fluid as alveolar bone loss biomarker in periodontal disease

Author :

  1. Agustin Wulan Suci Dharmayanti*1
  1. Department of Biomedical Faculty of Dentistry, Jember University, Jember - Indonesia

Abstract :

Background: Periodontal diseases have high prevalence in Indonesia. They are caused by bacteria plaque that induced host response to release pro inflammatory mediator. Pro inflammatory mediators and bacteria product cause degradation of collagen fibers in periodontal tissue. Deoxypyridinoline is one of pyridinoline cross-link of collagen type I that can be used as biomarker in bone metabolic diseases, however, their contribution to detect alveolar bone loss in periodontal diseases remains unclear. Purpose: This study was to evaluate deoxypyridinoline level in gingival crevicular fluid as alveolar bone loss biomarker on periodontal disease. Methods: This study used 24 subjects with periodontal diseases and 6 healthy subjects. Dividing of periodontal disease was based on index periodontal. Gingival crevicular fluid was taken at mesial site of maxillary posterior tooth by paper point and deoxypyridinoline be measured by ELISA technique. Results: We found increasing of deoxypyridinoline level following of the severity of periodontal diseases. There was also significant difference between healthy subjects and periodontal diseases subjects (p<0.05). Conclusion: Deoxypyridinoline level in gingiva crevicular fluid can be used as alveolar bone loss biomarker in periodontal disease subjects.

Keyword :

Deoxypyridinoline, gingival crevicular fluid, alveolar bone loss,


References :

AL- Bayaty HF,(2011) Prevalence and severity of periodontal disease among Iraqi twin population - : Scientific Research and Essays





Archive Article

Cover Media Content

Volume : 45 / No. : 2 / Pub. : 2012-06
  1. The Importance Of Masticatory Functional Analysis In The Diagnostic Finding And Treatment Planning For Prosthodontic Rehabilitation
  2. The Management Of Chronic Traumatic Ulcer In Oral Cavity
  3. Simplified Digital Infra Red Photography: An Alternative Tool In Bitemark Forensic Investigation
  4. The Relation Between Salivary Siga Level And Caries Incidence In Down Syndrome Children
  5. Inhibition Of 10% Alpinia Galanga And Alpinia Purpurata Rhizome Extract On Candida Albicans Growth
  6. Pulpal Inflammation After Vital Tooth Bleaching With 38% Hydrogen Peroxide
  7. The Increasing Of Enamel Calcium Level After Casein Phosphopeptide-amorphous Calcium Phosphate Covering
  8. Cytotoxicity Of Betel Leaf (piper Betel L.) Against Primary Culture Of Chicken Embryo Fibroblast And Its Effects On The Production Of Proinflammatory Cytokines By Human Peripheral Blood Mononuclear Cells
  9. Deoxypyridinoline Level In Gingival Crevicular Fluid As Alveolar Bone Loss Biomarker In Periodontal Disease
  10. Craniofacial Morphology Of Children With Complete Unilateral Cleft Lip And Palate Following Labioplasty And Palatoplasty
  11. Seroprevalence Of Herpes Simplex Virus Types 1 And 2 And Their Association With Cd4 Count Among Hiv-positive Patients

Information DENTJ