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Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 45 / No. 3 / Published : 2012-09

Order : 3, and page :133 - 137

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Original Article :

Distribution of class ii major histocompatibility complex antigen-expressing cells in human dental pulp with carious lesions

Author :

  1. Tetiana Haniastuti ia*1
  1. Department of Oral Biology Faculty of Dentistry, Gadjah Mada Universitas, Yogyakarta - Indones

Abstract :

Background: Dental caries is a bacterial infection which causes destruction of the hard tissues of the tooth. Exposure of thedentin to the oral environment as a result of caries inevitably results in a cellular response in the pulp. The major histocompatibilitycomplex (MHC) is a group of genes that code for cell-surface histocompatibility antigens. Cells expressing class II MHC moleculesparticipate in the initial recognition and the processing of antigenic substances to serve as antigen-presenting cells. Purpose: The aimof the study was to elucidate the alteration in the distribution of class II MHC antigen-expressing cells in human dental pulp as cariouslesions progressed toward the pulp. Methods: Fifteen third molars with caries at the occlusal site at various stages of decay and 5intact third molars were extracted and used in this study. Before decalcifying with 10% EDTA solution (pH 7.4), all the samples wereobserved by micro-computed tomography to confirm the lesion condition three-dimensionally. The specimens were then processed forcryosection and immunohistochemistry using an anti-MHC class II monoclonal antibody. Results: Class II MHC antigen-expressingcells were found both in normal and carious specimens. In normal tooth, the class II MHC-immunopositive cells were observed mainlyat the periphery of the pulp tissue. In teeth with caries, class II MHC-immunopositive cells were located predominantly subjacent tothe carious lesions. As the caries progressed, the number of class II MHC antigen-expressing cells was increased. Conclusion: Thedepth of carious lesions affects the distribution of class II MHC antigen-expressing cells in the dental pulp.

Keyword :

Class II major histocompatibility complex, dental pulp, caries,


References :

Marsh PD,(2008) The oral microflora and biofilms on teeth Oxford : Blackwell Munksgaard;





Archive Article

Cover Media Content

Volume : 45 / No. : 3 / Pub. : 2012-09
  1. The Benefit Of Differential Moment Concept In Managing Posterior Anchorage And Avoiding Bite Deepening
  2. Henoch-schönlein Purpura In Children: Its Relation To Oral And Dental Health
  3. Distribution Of Class Ii Major Histocompatibility Complex Antigen-expressing Cells In Human Dental Pulp With Carious Lesions
  4. Medication Intake And Its Influence On Salivary Profile Of Geriatric Outpatients In Cipto Mangunkusumo Hospita
  5. Maternal Endotoxin-induced Fetal Growth Restriction In Rats: Fetal Responses In Toll-like Receptor
  6. Novel Development Of Carbonate Apatite-chitosan Scaffolds Based On Lyophilization Technique For Bone Tissue Engineering
  7. Analgesic Effect Of Coconut Shell (cocos Nucifera L) Liquid Smoke On Mice
  8. Penetration Effect Of Prostaglandin E2 Gel On Oral Mucosa Of Rats
  9. Shear Bond Strength Of Self-adhering Flowable Composite On Dentin Surface As A Result Of Scrubbing Pressure And Duration
  10. Facial Reconstruction Using Polypropylene Mesh After Resection Of Maxillary Ossifying Fibroma
  11. Physical Characteristic Of Brown Algae (phaeophyta) From Madura Strait As Irreversible Hydrocolloid Impression Material

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