UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 41 / No. 2 / Published : 2008-04

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Original Article :

Effect of il-1 and gustducin expression change on bitter taste during fever

Author :

  1. Jenny Sunariani*1
  1. Department of Oral Biology
    Faculty of Dentistry Airlangga University
    Surabaya - Indonesia

Abstract :

ABSTRACT Homeostatic changes in the body, such as fever, cause inflammation, whose one of its impacts is the sense of bitterness inside the mouth. It implies in the reduction of appetite, which may finally result in the reduction of physical condition due to the inadequacy of food intake. It causes the inhibition of healing process, which reduces working productivity. The objective of this study was to identify the mechanism of bitterness due to inflammation, as proved locally in the taste buds of Wistar rats. This study was carried out experimentally using post-test only control design in experimental animals of male Wistar strain Rattus norvegicus. The animals were divided into two groups. First group served as control, while the second group received treatment with Salmonella typhimurium 0.5 ml/kg BW. Blood sample and tongue incision were taken from the animals. IL-1 was counted, and tongue incision was used for immunohistochemical staining for the variables of gustducin. Data were analyzed using Kolmogorov-Smirnov test for data normality, and followed with comparative test. The discriminant analysis was also done to find the discriminant variable. It was found that there was an increase of biological response of signaling transduction of bitterness in taste buds, as indicated from the increase of gustducin in treatment group or in inflammatory fever condition as compared to control group (p < 0.05), but no change of concertation at IL-1 significan whenever the was any change of concertation by unfolding its mechanism. Further studies can be recommended to find the way to inhibit this sense of bitterness. The results are intended to overcome homeostatic disorder in the body to prevent loss of appetite, so that physical endurance can be maintained. This study concludes that there is no increase of serum IL-1 expression in fever, but there is a significanly increase of taste buds gustducin. Further studies should focus on gustducin cellular role in other factors that play a role in taste buds signal transduction, either in homeostatic condition or in the condition of homeostatic disorder.

Keyword :

inflammation, bitter taste, gustducin, IL-1,


References :





Archive Article

Cover Media Content

Volume : 41 / No. : 2 / Pub. : 2008-06
  1. The Role Of Partial Denture In Management Of Hypohidrotic Ectodermal Dysplasia
  2. Management Of Zygomatic-maxillary Fracture (the Principles Of Diagnosis And Surgical Treatment With A Case Illustration)
  3. The Transversal Strength Of Acrylic Resin Plate After Soaking In The Juice Of The Noni Fruit (morinda Citrifolia Linn.)
  4. Pulp Tissue Inflammation And Angiogenesis After Pulp Capping With Transforming Growth Factor β1
  5. The Effect Of Exposure Duration Of Self Etch Dentin Bonding On The Toxicity Of Human Gingival Fibroblast Of Cell Culture
  6. Effect Of Il-1 And Gustducin Expression Change On Bitter Taste During Fever
  7. Differences In Cytotoxicity Between 5% Tetracycline Hydrochloride And 15% Edta As Root Canal Irrigant
  8. The Level Of Streptococcus Mutans And Lactobacillus In Saliva Of Dental Caries And Free Caries Children
  9. Combination Of Natural Teeth And Osseointegrated Implants As Prosthesis Abutments In A Posterior Cantilever Bridge
  10. Students’ Evaluation Of Preclinical Simulation For All Ceramic Preparation (in Faculty Of Dentistry Universiti Kebangsaan Malaysia)
  11. Potency Of Probiotic Therapy For Dental Caries Prevention
  12. The Use Of 90% Aloe Vera Freeze Drying As The Modulator Of Collagen Density In Extraction Socket Of Incicivus Cavia Cobaya

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