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Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 45 / No. 1 / Published : 2012-03

TOC : 11, and page :52 - 57

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Original Article :

Effect of robusta coffee beans extract ointment on full thickness wound healing

Author :

  1. Yorinta Putri Kenisa *1
  2. Istiati*2
  3. Wisnu Setyari J*3
  1. Student, Faculty of Dentistry, Airlangga University, Surabaya - Indonesia
  2. Department of Oral Biology Faculty of Dentistry, Airlangga University, Surabaya - Indonesia
  3. Department of Oral Biology Faculty of Dentistry, Airlangga University, Surabaya - Indonesia

Abstract :

Background: Traumatic lesions, whether chemical, physical, or thermal in nature, are among the most common lesion in the mouth. Wound healing is essential for the maintenance of normal structure, function, and survival of organisms. Experiments of Robusta coffee powder on rat-induced alloxan incision wound, clinically demonstrated similar healing rate with the povidone iodine 10%. No studies that look directly the effect of coffee extract in ointment form when viewed in terms of histopathology. Robusta coffee bean (Coffea canephora) consists of chlorogenic acid (CGA) and caffeic acid which are belived to act as antioxidant and take part in wound healing process. Purpose: The aim of this study was to identify the enhancement of healing process of full-thickness skin wound after Robusta coffee beans extract ointment application. Methods: Sample consisted of 20 Cavia cabaya treated with full-thickness with wounds and was given Robusta coffee beans extract ointment concentration range of 22.5%, 45%, and 90% except the control group which was given ointment base material. Animals were then harvested on the fourth day and made for histopathological preparations. Data were calculated and compared by one-way ANOVA test and LSD test. Results: The study showed that Robusta coffee bean extract ointment can increase the number of lymphocytes, plasma cells, macrophages, fibroblasts, and blood vessels by the presence of chlorogenic acid (CGA) and Caffeic acid. Conclusion: In conclusion Robusta coffee bean extract ointment enhance the healing process of fullthickness skin wound of Cavia cabaya.

Keyword :

Robusta coffee bean extract, the healing process, chlorogenic acid, caffeic acid,


References :

  1. Boateng SJ, (2007). Wound healing dressing and drug delivey system: A Review. - : Journal of Pharmaceutical Sciences
  2. Sabir A, (2005). Aktivitas antibakteri flavonoid propolis Trigona spterhadap bakteri Streptococcus mutans(in vitro). . surabaya : Maj Ked Gigi (Dent J)


   


Archive Article

Cover Media Content

Volume : 45 / No. : 1 / Pub. : 2012-03
  1. Immediate overdenture for improving aesthetic of anterior teeth with periodontal problem
  2. Orthodontic treatment considerations in down syndrome patients
  3. The effective concentration of red betel leaf (piper crocatum) infusion as root canal irrigant solution
  4. Degrees of chitosan deacetylated from white shrimp shell waste as dental biomaterials
  5. Antimicrobial effect of chlorine dioxide on actinobacillus actinomycetemcomitans in diabetes mellitus rats treated with insulin
  6. Genetic variability of candida albicans in hiv/aids patient with and without arv therapy and non hiv/aids
  7. Relationship between salivary fluor concentration and caries index in 12–15 years old children
  8. Crude toxin of aggregatibacter actinomycetemcomitans serotype-b increase parp-1 expression in gingival epithelium
  9. Effectiveness of bleaching agent on composite resin discoloration
  10. Analysis of importance level and quality achievement aspect in dental health service (a case study on waru sidoarjo community dental health service)
  11. Effect of robusta coffee beans extract ointment on full thickness wound healing