UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 44 / No. 2 / Published : 2011-06

Order : 7, and page :88 - 92

Related with : Scholar   Yahoo!   Bing

Original Article :

Effectivity of 0.15% benzydamine on radiation-induced oral mucositis in nasopharynx carcinoma

Author :

  1. Remita Adya Prasetyo *1
  1. Division of Oral Medicine Installation/Department of Dental & Oral Health, Dr. Soetomo Hospital Hospital Surabaya - Indonesia

Abstract :

Background: Nasopharynx carcinoma is the most common malignant tumour in head and neck region. Radiotherapy is the first choice of treatment for nasopharynx carcinoma that had not been metastases. The most common oral complications in radiotherapy is mucositis (± 80%). 0.15% benzydamine hydrochloride (HCl) oral rinse can be used to prevent radiation-induced oral mucositis. Purpose: The aim of this research was to study the effectivity of 0.15% benzydamine HCl oral rinse for prevention of radiation-induced oral mucositis in nasopharynx carcinoma. Methods: Samples were divided into 2 groups. Group A was using 0.15% benzydamine HCl oral rinse for 10 days. Group B was using placebo oral rinse for 10 days. Evaluation was conducted 3 times: first day, fifth day and tenth day of radiotherapy. The scoring used Spijkervet’s mucositis α score. Results: Independent t test analysis for initial occurrence of oral mucositis showed no significant difference between 2 groups. Paired t test analysis showed significant difference between initial mucositis α score and mucositis α score in tenth day in each group. Independent t test analysis showed no significant difference in mucositis α score in tenth day between 2 groups. Conclusion: In conclusion 0.15% benzydamine HCl oral rinse was not effective to prevent radiation-induced oral mucositis in nasopharynx carcinoma.

Keyword :

0.15% benzydamine hydrochloride, prevention, radiation-indu,


References :

Kartabrata M,(2001) Prevalensi kandidiasis mulut pada penderita yang mendapat terapi radioterapi kanker kepala dan leher. Surabaya : Maj Ked Gigi (Dent J)





Archive Article

Cover Media Content

Volume : 44 / No. : 2 / Pub. : 2011-06
  1. The Effectivity Of Toothpick Tooth Brushing Method On Plaque Control
  2. Effects Of Different Saliva Ph On Hybrid Composite Resin Surface Roughness
  3. Endothelial Cell Cultured On Ha/tcp/chitosan Scaffold For Bone Tissue Engineering
  4. Elderly Nutritional Status Affect Salivary Anticandidal Capacity Against Candida Albicans
  5. Saliva As A Future Potential Predictor For Various Periodontal Diseases
  6. Relieving Idiopathic Dental Pain Without Drugs
  7. Effectivity Of 0.15% Benzydamine On Radiation-induced Oral Mucositis In Nasopharynx Carcinoma
  8. Constraints On The Performance Of School-based Dental Program In Yogyakarta Province, Indonesia: (a Qualitative Study)
  9. Orthodontic Treatment With Skeletal Anchorage System
  10. The Activity Of Stichopus Hermanii Extract On Triglyceride Serum Level In Periodontitis
  11. Effect Of Soybean Extract After Tooth Extraction On Osteoblast Numbers

Information DENTJ