UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 46 / No. 4 / Published : 2013-12

Order : 1, and page :175 - 180

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Original Article :

Ekspresi cox-2 setelah pemberian ekstrak etanolik kulit manggis

Author :

  1. Rendra Chriestedy Prasetya*1
  2. Tetiana Haniastuti*2
  3. Nunuk Purwanti*3
  1. Bagian Biomedik, Fakultas Kedokteran Gigi Universitas Jember-Indonesia
  2. Bagian Biologi Mulut, Fakultas Kedokteran Gigi Universitas Gadjah Mada, Jogjakarta-Indonesia
  3. Bagian Biomedik, Fakultas Kedokteran Gigi Universitas Gadjah Mada, Jogjakarta-Indonesia

Abstract :

Background: Cyclooxygenase is an enzim that synthesis of prostaglandins (PGs) from arachidonic acid. Cyclooxygenase have been characterized and named COX-1 and COX-2. COX-1 is responsible for constitutive PGs production under physiological condition and  maintain normal function. On the other hand, COX-2 expression is inducible by cytokines and endotoxin. Periodontitis is a chronic  inflammatory disease caused by anaerobic bacteria especially gram negative bacteria. When periodontitis occurred are followed by  increased COX-2 expression. Mangosteen rind contains gamma mangostin which inhibits the synthesis of PGE2 thorugh inhibition  COX-2 expression. Purpose: This researches aimed to study COX-2 expression in experimental-induced periodontitis in rats after  mangosteen rind etanolic extract administration. Methods: Forty eight male wistar rats were induced periodontitis by putting silk  ligature subgingivally around the neck of the anterior lower teeth for 7 days. After the ligation was taken out, the rats were divided  into 4 groups, and treated orally with mangosteen rind extract 60 mg/kg BB, 30 mg/kg BB, ibuprofen and saline. The rats were  sacrified on the 1st, 3rd, 4th, 7th day after the treatment. Their anterior lower jaws were processed for paraffin embedded tissue, cut  serially and stained with immuniohistochemistry. COX-2 expression were observed and counted under the microscope (400x).the data  were analysed using kruskall wallis test. Result: Kruskal wallis test showed a significant difference COX-2 expression among group  indicating that mangosteen rind etanolic extract affected COX-2 expression. Conclusion: Mangosteen rind etanolic extract reduced  COX-2 expression in periodontitis rats.

Keyword :

periodontitis, mangosteen rind etanolic extract , Cyclooxygenase-2,


References :

Khan A ,(2007) Expression of COX-1 and COX-2 in a clinical model of acute inflammation - : J Pain





Archive Article

Cover Media Content

Volume : 46 / No. : 4 / Pub. : 2013-12
  1. Prevotella Intermedia And Porphyromonas Gingivalis In Dental Caries With Periapical Granuloma
  2. Facial Soft Tissue Profile On Borderline Class I Malocclusion Between Extraction And Non-extraction Orthodontic Treatment
  3. Ekspresi Cox-2 Setelah Pemberian Ekstrak Etanolik Kulit Manggis
  4. Fish Oil Of Sardinella Longicep Regulates Osteoblast Apoptosis Of Rat Alveolar Bone Induced Lypopolisacharide
  5. Inflammatory Response Of The Dental Pulp After Application Of 19% Ethylene Diamine Tetraacetic Acid And 37% Phosphoric Acid As Etching Agents
  6. Potential Of Extracts Cassava Leaf (manihot Utilissima) On The Expression Of Cox-2 On Monocytes That Exposed By Lps E. Coli
  7. The Effect Of Desensitizing Agent Containing Fluoride On Streptococcus Mutans Adhesion And Enamel Roughness
  8. Physical Properties Of Calcite Synthesized Hydroxyapatite As The Filler Of Epoxy-resin-based Root Canal Sealer
  9. Antifungal Property Of Sticophus Hermanii And Holothuria Atra Extract And Its Cytotoxicityto Gingiva-derived Mesenchymal Stem Cell
  10. Orthodontic-surgical Treatment Of A Severe Class Iii Malocclusion
  11. Perbandingan Korelasi Antara Indeks Morfologi Wajah Genap Dengan Sudut Interinsisal Dan Tinggi Wajah Secara Sefalometri

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