UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 46 / No. 3 / Published : 2013-09

Order : 6, and page :140 - 147

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Original Article :

Epstein-barr virus (ebv) dna as biomaker of nasopharyngeal carcinoma diagnosis

Author :

  1. Janti Sudiono*1
  1. Bagian Patologi Oral, Fakultas Kedokteran Gigi Universitas Trisakti, Jakarta - Indonesia

Abstract :

Background: Nasopharyngeal carcinoma (NPC) is a malignant neoplasm arising from the mucosal epithelium of the nasopharynx with various cells differentiation. Nasopharyngeal carcinoma is vastly more common in certain regions ofEast Asia, South Asia and Africa with viral, dietary which is typically includes consumption of salted vegetables, fish, meat and genetic factors that implicated in its causation. The undifferentiated is the most common type of NPC and strongly associated with Epstein-Barr virus (EBV) infection. Purpose: This paper was aimed to review about molecular biomarker as non invasive diagnosis of NPC especially in related to EBV infection in nasopharyngeal epithelial cells. reviews: The pathogenesis of NPC particularly the endemic type seems to follow a multi-step process, in which EBV, ethnic background, and environmental carcinogens all seem to play important role. EBV DNA plasm level is used continuously in clinic as a promise, sensitive and specific molecular marker diagnostic that reflected the stage, treatment response and prognosis of NPC. Detection of nuclear antigen associated with Epstein-Barr virus (EBNA) and viral DNA has revealed that EBV can infect epithelial cells and associated with their transformation in carcinogenesis. Latent membrane protein (LMP-1 and LMP-2) oncogenes EBV encoded related to proliferative gene expression indicated invasive and progressive growth of NPC. Conclusion: The new biomarkers for NPC, including EBV DNA in serum; EBV DNA and BamH1-A Reading Frame-1 (BARF1) mRNA in NPC brushings have been developed for the molecular non invasive diagnosis of this tumour.

Keyword :

Nasopharyngeal carcinoma, Epstein-Barr virus, environmental carcinogen, molecular biomarker,


References :

Adham M,(2012) Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation - : Chin J Cancer





Archive Article

Cover Media Content

Volume : 46 / No. : 3 / Pub. : 2013-09
  1. Correlation Between Salivary Leptin Levels And Incidence Of Caries In Obese Children
  2. The Role Of Calcium On Enamel Hypoplasia Prevention
  3. The Correlation Of Micronucleus Formation And 8-oxo-dg Expression Due To The Panoramic Radiography Exposure
  4. Fluoride Determination Of Children And Adult Toothpaste By Spectrophotometry
  5. Heteroplasmy Analysis Of Dental Pulp Mitochondrial Dna In Forensic Personal Identification
  6. Effect Of Gestational Diabetes Mellitus On The Expression Of Amelogenin In Rat Offspring Tooth Germ
  7. The Effect Of Chitosan Gel Concentration To Neutrophyl And Macrophage In Gingival Ulcer
  8. Epstein-barr Virus (ebv) Dna As Biomaker Of Nasopharyngeal Carcinoma Diagnosis
  9. Metal Crown Restoration With Fiber Post In Young First Permanent Molar
  10. Cranial Size And Cephalic On Index Mentally Retarded 7–12 Years Old Children
  11. Mechanism Of Pomegranate Extract In Killing Malignant Cells In Mice Through Oral Cavity Mucosa Increased Expression Of P53 Wild

Information DENTJ