UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 41 / No. 1 / Published : 2008-01

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Original Article :

Expression toll-like receptors in the oral mucosal of patients with recurrent aphthous stomatitis

Author :

  1. Diah Savitri Ernawati*1
  1. Department of Oral Medicine
    Faculty of Dentistry Airlangga University
    Surabaya-Indonesia

Abstract :

Toll-Like Receptors (TLRs) have recently emerged as key receptors of the innate immune system. They recognize specific pathogen-associated molecular patterns initiating a host defence response. The oral mucosal epithelium encounters potential pathogens like bacteria and viruses in inspired air, and the discovery of TLRs on epithelial cells suggest that the epithelium has a role in the mucosal immune system. The aim of this study was to disclose or discover RAS using etiopathogenetic molecular approach by observing the TLRs. Immunohistochemistry using monoclonal antibodies anti-TLR-2, TLR-3, TLR-4, TLR-5, TLR-7 and TLR-9 were used in this study. These antibodies are specific toward TLR on the surface of epithelial cells membrane and macrophages in patients with major and minor RAS. TLR is expressed on the surface of epithelial cells membrane of oral mucosa and macrophages in both major and minor RAS patients. TLRs was not expressed specifically in non-RAS patients. The results above showed indication, that functional TLRs expression by epithelial cells in oral mucosa had remarkable implication on natural immune response and disease pathogenesis. The expression of TLR was found in the oral mucous membrane on epithelial cells surface and macrophages patients with RAS.

Keyword :

major and minor RAS, Toll-like receptors,


References :

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Archive Article

Cover Media Content

Volume : 41 / No. : 1 / Pub. : 2008-03
  1. Three Dimensional Changes In Maxillary Complete Dentures Immersed In Water For Seven Days After Polymerization
  2. The In Vitro Assessment Of Anti Proliferation Activity Of Crude Diethyl Ether Extract Of Dendrophthoe Species To Myeloma Culture Cell
  3. Coen’s Ascending Ramus Fixator Use For Repositioning The Ascending Ramus During Mandible Reconstruction
  4. The Role Of Transforming Growth Factor Beta In Tertiary Dentinogenesis
  5. Morphological Changes Of Alveolar Bone Due To Orthodontic Movement Of Maxillary And Mandibulary Incisors
  6. The Effect Of Psidium Guajava Linn Leaf Extract On Candida Albicans Adherence And The Transversal Strength Of Acrylic Resin
  7. Side Effects Of Mercury In Dental Amalgam
  8. Pulp Tissue Vacuolization And Necrosis After Direct Pulp Capping With Calcium Hydroxide And Transforming Growth Factor-1
  9. Antimicrobial Effect Of Calcium Hydroxide As Endo Intracanal Dressing On Streptococcus Viridans
  10. Gingival Immunologic Defense Index: A New Indicator For Evaluating Dental Plaque Infection Risk In Allergic Children
  11. Expression Toll-like Receptors In The Oral Mucosal Of Patients With Recurrent Aphthous Stomatitis

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