UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 43 / No. 1 / Published : 2010-03

Order : 6, and page :26 - 30

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Original Article :

Human-leukocyte antigen typing in javanese patients with recurrent aphthous stomatitis

Author :

  1. Diah Savitri Ernawati*1
  2. Bagus Soebadi*2
  3. Desiana Radithia*3
  1. Departement of Oral Medicine
    Faculty of Dentistry, Airlangga University
    Surabaya - Indonesia
  2. Departement of Oral Medicine
    Faculty of Dentistry, Airlangga University
    Surabaya - Indonesia
  3. Departement of Oral Medicine
    Faculty of Dentistry, Airlangga University
    Surabaya - Indonesia

Abstract :

Background: Recurrent aphthous stomatitis (RAS) is a common oral disorder that despite extensive researches, the etiology of this phenomenon is still unknown. Because this phenomenon has been observed more often in families than in individual cases, genetic influence has been investigated in most researches. A significant association of certain human leukocyte antigen (HLA) and haplotypic pairs with RAS has been reported. Purpose: The aim of the present study was to evaluate the association between human leukocyte antigen (HLA) and recurrent aphthous stomatitis more precisely. Method: The analysis of HLA-A, and HLA-B in 85 Javanese RAS patients and 71 healthy control subjects, was performed by using the standard NIH microlymhocytotoxicity technique. Immunohistochemistry was performed for identification of HLA-DR and HLA- DQ antigen using monoclonal antibodies anti HLA-DR and DQ. Result: Our result revealed a close association between HLA-A9 and HLA-B35 RAS subject. A significant increase in the frequency of some antigens such as HLA-A9 (72,94%,p<0,05;RR=2,21), HLA-A24(65,82%;RR=1,24) and HLA-B35 in subjects with RAS was observed. Analysis with Imunohistochemistry HLA-DR, HLA-DQ is expressed on the surface of epithelial cells membrane of oral mucosa and macrophages in both major and minor RAS patients. Conclusion: HLA antigens are involved in susceptibility to RAS and the phenotypes were difference with other previous studies. HLA-linked genetic factors may play a role in the development of RAS.

Keyword :

Human leukocyte antigen, recurrent aphthous stomatitis, oral mucosal epithelium,


References :

Robinson ND,(2003) Recalcitrant, recurrent aphthous stomatitis treated with etanercept. - : Arch Dermatol





Archive Article

Cover Media Content

Volume : 43 / No. : 1 / Pub. : 2010-03
  1. The Comparison Between Minocycline Oral-rinse And Gel On Pocket Depth
  2. The Frequency Of Bottle-feeding As Main Factor In Baby Bottle Tooth Decay Syndrome
  3. Relationship Between Trauma Mechanism And Etiology On Mandibular Fracture Patterns
  4. Noma Management In A Child With Systemic Lupus Erythematosus
  5. Tissue Engineered Bone As An Alternative For Repairing Of Bone Defects
  6. Mozart Effect On Dental Anxiety In 6-12 Year-old Children
  7. The Comparison Of Minocycline Oral Rinse And Gel To Reduce Pocket Depth
  8. Human-leukocyte Antigen Typing In Javanese Patients With Recurrent Aphthous Stomatitis
  9. Mengkudu (morinda Citrifolia Linn.) Gel Effect On Post-extraction Fibroblast Acceleration
  10. Special Considerations For Orthodontic Treatment In Patients With Root Resorption
  11. Various Curing Methods On Transverse Strength Of Acrylic Resin
  12. The Frequency Of Bottle Feeding As The Main Factor Of Baby Bottle Tooth Decay Syndrome

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