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Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 47 / No. 3 / Published : 2014-09

Order : 2, and page :126 - 129

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Original Article :

Modulation of fgf2after topical application ofr topical application of topicalapplication ofapplication of�tichopus hermaniigelontichopus hermaniigelon traumatic ulcer in wistar rats

Author :

  1. Rima Parwati Sari*1
  2. Endah Wahjuningsih*2
  3. Isidora Karsini Soeweondo*3
  1. Bagian Biologi Mulut, Fakultas Kedokteran Gigi Universitas Hang Tuah, Surabaya-Indonesia
  2. Bagian Biologi Mulut, Fakultas Kedokteran Gigi Universitas Hang Tuah, Surabaya-Indonesia
  3. Dosen Fakultas Kedokteran Gigi

Abstract :

Background: Stichopus hermanii (golden sea cucumber) is one of the many types of marine organisms containing glycosaminoglycans (GAGs), a polysaccharide that is very beneficial in wound healing. The content of this GAGs, mainly dermatan sulfate, chondroitin sulfate and heparan sulfate has the ability to modulate FGF2. FGF2 many found in the oral mucosa to activate fibroblast proliferation. Purpose: To determine the modulation of FGF2after topical application of Stichopus hemaniigelin traumatic ulcers. Methods: The sample was 36 male Wistar rats were divided into 6 groups. C1 and C2 group was placebo gel, SC1 and SC2 group was Stichopus hermanii gel, HA1 and HA2 was hyaluronic acid A gel. Giving gel made shortly after the traumatic ulcer(TU) formed and 24 hourafter TU formed for one day. Then all rats were sacrificed for lips and mucosa taken ELISA examination. Results: All data were analyzed by ANOVA test followed by Tukey HSD test results show significant differences between SC1-SC2 with C1-C2 group, while the HA1-HA2 with C1-C2 group showed no significant difference. Conclusion: Modulation of FGF2 increased after topical application of Stichopus hermaniigel on traumatic ulcers in wistar rats. 

Keyword :

FGF2, Stichopus hermanii gel, traumaticulcer, traumaticulcer,


References :

Regezi JA ,(2008) Oral pathologic clinical pathologic correlations St. Louis : WB Sauders





Archive Article

Cover Media Content

Volume : 47 / No. : 3 / Pub. : 2014-09
  1. Microscopic Evaluation Of The Interface Between Various Of Glass Ionomer And Dentin Surface: Influence Of Nanoparticle Horseshoe Crab (tachypleus Gigas) Chitosan Addition
  2. Modulation Of Fgf2after Topical Application Ofr Topical Application Of Topicalapplication Ofapplication Of�tichopus Hermaniigelontichopus Hermaniigelon Traumatic Ulcer In Wistar Rats
  3. Comparison Of Three Types Algyrogel Cytotoxicity Against Fibroblasts
  4. The Effect Of Aspirin Administration Length On Ki-67 Expression Protein And Oral Epithelial Mucosal Thickness In Male Wistar Mice
  5. Characterization Of Lactoferrin In Gingival Crevicular Fluid Of Chronic Periodontitis Patient
  6. Oral Health Knowledge Among Parents Of Autistic Child In Bandung-indonesia
  7. Effect Of Siwak (salvadora Persica) Traditional Toothbrush On The Accumultated Dental Plaque
  8. The Management Of Impacted Permanent Canine With Surgical Exposure
  9. Inhibition Effect Of Xylitol And Nistatin Combination On Candida Albicans Growth (in Vitro)
  10. The Release Of Nickel And Chromium Ions In Special Type Of Australian Wire And Stainless Steel In Artificial Saliva
  11. Identifikasi Bakteri Saat Insial Akuisisi Streptococcus Mutans Pada Bayi

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