UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 45 / No. 4 / Published : 2012-12

Order : 3, and page :192 - 196

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Original Article :

Molecular characterization of interleukin-1a (+4845) gtgene in aggresive periodontitis patients

Author :

  1. Chiquita Prahasanti*1
  2. Harianto Notopuro*2
  1. Department of Periodontics, Faculty of Dentistry, Universitas Airlangga
  2. Department of Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya - Indonesia

Abstract :

Background: Abundant researches had been conducted based on the clinical and histopahological pathogenesis of aggresive periodontitis. Nevertheless, there were still few researches which based on molecular biology, and especially related to gene polymorphism. Purpose: This study was done based on IL-1A (nt4845) gene polymorphism in Aggressive Periodontitis patients. This study was expected to be useful as an indicator for early detection, prevention and management of aggressive periodontitis patients. Methods: Data were obtained from a case control study of 37 patients with aggressive periodontitis and 34 patients with chronic periodontitis. The IL-1A (nt4845) TG gene polymorphism was detected with PCR-RFLP technique. Data were obtained from a case control study of 37 aggressive periodontitis patients and 34 chronic periodontitis patients in RSGMP clinic, Faculty of Dentistry, Airlangga University. Results: Homozygout allele 2 polymorphism was not found in all samples, only allele 1 and allele 1+2 which affect Aggressive Periodontitis patients. Conclusion: Base on our data that there was no significant association between IL-1A (nt4845) gene polymorphism and aggressive periodontitis and chronic periodontitis.

Keyword :

Interleukin-1A (+4845)G-->T, gene polymorphisms, aggressive periodontitis, chronic periodontitis, PCR-RFLP,


References :

Newman MG,(2011) Carranza’ clinical periodontology London : WB Saunders





Archive Article

Cover Media Content

Volume : 45 / No. : 4 / Pub. : 2012-12
  1. The Role Of Actinobacillus Actinomycetemcomitans Fimbrial Adhesin On Mmp-8 Activity In Aggressive Periodontitis Pathogenesis
  2. Aesthetic Treatment On Anterior Teeth Crown Fracture Caused By Dental Trauma
  3. Molecular Characterization Of Interleukin-1a (+4845) Gtgene In Aggresive Periodontitis Patients
  4. Antitumor Activity Of Intratumoral Injection Of Pcdna3.1-p27kip1mt Followed By In Vivo Electroporation In A Malignant Burkitt’s Lymphoma Cell Xenograft
  5. The Effect Of Nickel As A Nickel Chromium Restoration Corrosion Product On Gingival Fibroblast Through Analysis Of Bcl-2
  6. Inhibition Of Dental Plaque Formation By Toothpaste Containing Propolis
  7. Inhibition Effect Of Cashew Stem Bark Extract (anacardium Occidentale L.) On The Inhibition Of Biofilm Formation Of Streptococcus Sanguinis
  8. Antibacterial Efficacy Of Salvadora Persicaas A Cleansing Teeth Towards Streptococcus Mutansand Lactobacilli Colonies
  9. Pomegranate Juice As An Ideal Mouthrinse For Fixed Orthodontic Patients
  10. The Increasing Of Fibroblast Growth Factor 2, Osteocalcin, And Osteoblast Due To The Induction Of The Combination Of Aloe Vera And 2% Xenograft Concelous Bovine
  11. The Ph Changes Of Artificial Saliva After Interaction With Oral Ph Changes Of Artificial Saliva After Interaction With Oral Changes Of Artificial Saliva After Interaction With Oral Micropathogen

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