UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 46 / No. 2 / Published : 2013-06

Order : 7, and page :86 - 92

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Original Article :

New concept in allergy: non-allergic rats becomes allergic after induced by porphyromonas gingivalis lipopolysaccharide

Author :

  1. Haryono Utomo*1
  1. Dosen Fakultas Kedokteran Gigi

Abstract :

Background: As a theory, seemingly it is impossible that allergic diseases, including asthma, are the result of exposure to a transmissible agent. The fact that nearly all childrenwith asthma are allergic, but only a small proportion of allergic children have  asthma, at least raises the possibility that other factors are involved. Interestingly, non-allergic children become allergic after their  parents came from working in allergic people for several months. Recent research revealed that periodontal pathogens are also  transmissible from mother and caregivers to infants.Therefore, it is logical that non-allergic children could become allergic after  exposed to periodontopathic bacteria. However, the mechanism is still unclear. Purpose: The objective of this study is to verify a  new concept that non-allergic rat may become allergic after exposed to Porphyromonas gingivalis lipopolysaccharide. Methods: Randomized control series design experimental study was conducted to 24 male Wistar rats, two experimental groups and one control  group. One group was subjected to intrasulcular injection of PgLPS 1435/1450. Tissue examination were done for allergy biomarkers with peroxidase immunohistochemistry for leukotriene C4 (LTC4) and eosinophilic cationic protein (ECP) in bronchus tissue. Serum level examination of interleukin 4 (IL-4), and immunoglobulin E (IgE) was done with ELISA. Data were analyzes using ANOVA.  Results: after four days, LTC4 and ECP expression increased significantly (p=0.001); even insignificant, IL-4 and IgE serum level also increased. Conclusion: PgLPS is able to stimulate immunocompetent cells which changed the host immune response of non-allergic rats. Therefore, it is possible that they become allergic.

Keyword :

Transmission, allergic, periodontopathic bacteria, lipopolysaccharide,


References :

Umetsu DT,(2012) Early exposure to germs and the hygiene hypothesis - : Cell Res





Archive Article

Cover Media Content

Volume : 46 / No. : 2 / Pub. : 2013-06
  1. Enamel Defect Of Primary Dentition In Sga Children In Relation To Onset Time Of Intrauterine Growth Disturbance
  2. Description Of Pulp Chamber Density In Deciduous Teeth Using Cone Beam Ct-3d
  3. A Study Of Extraction And Characterization Of Alginates Obtained From Brown Macroalgae Sargassum Duplicatum And Sargassum Crassifolium From Indonesia
  4. Effectiveness Of Various Sterilization Methods Of Contaminated Post-fitted Molar Band
  5. Peroxide Alkaline For Cleansing The Baby Bottle Nipple To Prevent Oral Thrush Relaps
  6. Treatment Of Non-vital Primary Molar Using Lesion Sterilization And Tissue Repair (lstr 3mix-mp)
  7. New Concept In Allergy: Non-allergic Rats Becomes Allergic After Induced By Porphyromonas Gingivalis Lipopolysaccharide
  8. Ricketts Esthetic Line At Student Of Faculty Of Dentistry Universitas Airlangga
  9. Dental Student’s Perception To Aesthetic Component Of Iotn And Demand For Orthodontic Treatment
  10. Compressive Strength Of Hybrid Composites Resin With Post Curing Light Emitting Diode Using Three Different Sizes Of Lightbox
  11. Bitemark Identification With Chelex Methods In Dna Extraction

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