Dental Journal (Majalah Kedokteran Gigi)
ISSN 1978-3728
Vol. 37 / No. 4 / Published : 2004-10
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Original Article :
Oral phemphigus vulgaris in histophatological and immunopathological approach
Author :
Abstract :
Phemphigus Vulgaris (PV) is a most commonly found autoimmune disease in the oral cavity. Delayed management may lead to facial condition for the patient, and the morbidity rate is reported from 5-15%. The difficulty to establish the diagnosis of and treatment of PV due to the similarity with other bullous lesions. Therefore it is important to performed immunopathological approach. Bullous lesion in the intraepidermal/intraepithelial layer followed by destruction of keratinocyte occurs as a result of the binding of IgG autoantibody and C3 factor, which later cause intercellular binds to collapse and causing acantholysis. Intercellular binds are formed by desmoglein-3 and desmosome and rupture of this bind is a factor in the Tzank cell formation. Immunofluoresence examination can be performed to diagnose the disease. Corticosteroid remains the ideal treatment apart from oral hygiene maintenance and certain dietary intake to prevent more severe infection.
Keyword :
phemphigus vulgaris, desmoglein-3, desmosome, Tzank cell, IgG and C,
References :
Archive Article
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 Volume : 37 / No. : 4 / Pub. : 2004-12 |
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