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Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 45 / No. 3 / Published : 2012-09

Order : 8, and page :161 - 166

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Original Article :

Penetration effect of prostaglandin e2 gel on oral mucosa of rats

Author :

  1. Rafinus Arifin*1
  2. Retno Widayati*2
  3. Erni H Purwaningsih*3
  4. Dewi Fatma S*4
  1. Orthodontic Resident, Department of Orthodontics Faculty of Dentistry, Universitas Indonesia, Jakarta - Indonesia
  2. Department of Orthodontics Faculty of Dentistry, Universitas Indonesia, Jakarta - Indonesia
  3. Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta - Indonesia
  4. Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta - Indonesia

Abstract :

Background: Several researches reported that PGE2 (Prostaglandin E2) injection on buccal mucosa combined with orthodontic pressure can faster tooth movement but has disadvantages such as high alveolar bone and root resorption furthermore pain from injection needle. PGE2 gel was made to better replace the lacks of injectable PGE2. Purpose: this research was aimed to prove that PGE2 gel can penetrate rat’s oral mucosa effecting the appearance of PMN cells. Methods: this research was an in-vivo laboratory experiment using 36 Sprague Dawley rats which were divided into 3 groups: normal group, topical PGE2 gel group after 1, 2, 4, 8 hours (4 subgroups), and topical gel without PGE2 group after 1, 2, 4, 8 hours (4 subgroups). Each group consists of 4 rats, therefore the total sample for all research groups were 36 rats. Results: Penetration effect of PGE2 gel on rat’s oral mucosa result in PMN inflammation cells distribution. One-way ANOVA showed no significant difference on PMN cells count in rats’ lower jaws between groups of normal and gel without PGE2. There was significant difference between groups of PGE2 gel and gel without PGE2 (p=0,001). PGE2 gel application showed PGE2 as inflammatory media, even though administered topically. Conclusion: PGE2 gel can penetrate rat’s oral mucosa, effecting PMN cells 1, 2, 4 and 8 hours after application of PGE2 gel.

Keyword :

PGE2, PMN ,


References :

Vu CQ,,(2008) Treatment complexity index for assessing the relationship of treatment duration and outcomes in a graduate orthodontic clinic - : Am J Orthod Dentofacial Orthop





Archive Article

Cover Media Content

Volume : 45 / No. : 3 / Pub. : 2012-09
  1. The Benefit Of Differential Moment Concept In Managing Posterior Anchorage And Avoiding Bite Deepening
  2. Henoch-schönlein Purpura In Children: Its Relation To Oral And Dental Health
  3. Distribution Of Class Ii Major Histocompatibility Complex Antigen-expressing Cells In Human Dental Pulp With Carious Lesions
  4. Medication Intake And Its Influence On Salivary Profile Of Geriatric Outpatients In Cipto Mangunkusumo Hospita
  5. Maternal Endotoxin-induced Fetal Growth Restriction In Rats: Fetal Responses In Toll-like Receptor
  6. Novel Development Of Carbonate Apatite-chitosan Scaffolds Based On Lyophilization Technique For Bone Tissue Engineering
  7. Analgesic Effect Of Coconut Shell (cocos Nucifera L) Liquid Smoke On Mice
  8. Penetration Effect Of Prostaglandin E2 Gel On Oral Mucosa Of Rats
  9. Shear Bond Strength Of Self-adhering Flowable Composite On Dentin Surface As A Result Of Scrubbing Pressure And Duration
  10. Facial Reconstruction Using Polypropylene Mesh After Resection Of Maxillary Ossifying Fibroma
  11. Physical Characteristic Of Brown Algae (phaeophyta) From Madura Strait As Irreversible Hydrocolloid Impression Material

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