UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 44 / No. 4 / Published : 2011-12

Order : 11, and page :215 - 219

Related with : Scholar   Yahoo!   Bing

Original Article :

Piperin and piplartin as natural oral anticancer drug

Author :

  1. Berlian Bidarisugma *1
  2. Sarah Usman Balbeid *2
  3. Anis Irmawati *3
  1. Student, Faculty of Dentistry, Airlangga University, Surabaya - Indonesia
  2. Student, Faculty of Dentistry, Airlangga University, Surabaya - Indonesia
  3. Department of Oral Biology Faculty of Dentistry, Airlangga University, Surabaya - Indonesia

Abstract :

Background: Since the last few decades, oral cancer as pathology has become an attention in medicine and dentistry. The majority cases of oral cancer are affecting people with smoking habit and alcohol consumption. Many herbs contain substances which can stop cancer cells proliferation, such as Piper retrofractum/Retrofracti fructus, an herb plant from Piperaceae family which contains piperin and piplartin. Purpose: The purpose of this study was to examine the mechanism of piperin and pilplartin as natural oral anticancer drug. Reviews: Piperin and piplartin has function as antioxidant that can protect body cell from damage caused by free radicals. Piperin works synergistically with another bioactive substance like capsaicin and curcumin. Piperin increase the number of serum and life time of serum from a few nutrition substance like co-enzyme Q10 and beta-carotene. Beta-carotene can catch reactive O2 and peroxil radicals. The activity of anticancer piplartin related with obstruction of proliferation cell rate, observe form Ki67 reduction as antigen in nucleus that associated with G1, S, G2, and M phase in cell cycle. Comparing with piplartin, piperin is more potential to inhibit proliferation rate of Ki67, but piplartin’s antiproliferation mechanism will increase if supported by piperin. Conclusion: Piperin and piplartin contained in Javanese chili are potential for natural oral anticancer, by directly or indirectly suppress tumor cell development by increasing the number of immunity cells (immunomodulator), and by inhibiting cell proliferation with reduction of Ki67, nucleus antigen that associated with G1,S,G2, dan M phase of cell cycle.

Keyword :

Oral cancer, piperin, piplartin,


References :

Khajuria A ,(1998) Permeability characteristics of piperine on oral absorption-an active alkaloid from peppers and a bioavailability enhancer - : . Ind J Exp Biol





Archive Article

Cover Media Content

Volume : 44 / No. : 4 / Pub. : 2011-12
  1. Betel Leaf Toothpastes Inhibit Dental Plaque Formation On Fixed Orthodontic Patients
  2. In Vivo Characterization Of Polymer Based Dental Cements
  3. Oral Rinse As A Potential Method To Culture Candida Isolate From Aids Patients
  4. In Vitro Effect Of Q-switched Nd:yag Laser Exposure On Morphology, Hydroxyapatite Composition And Microhardness Properties Of Human Dentin
  5. The Effectiveness Of Mimba Oil (azadirachta Indica A. Juss) Spray Disinfectant On Alginate Impression
  6. The Effect Of Spirulina Gel On Fibroblast Cell Number After Wound Healing Process
  7. The Difference Of Residual Monomer Levels Of Acrylic Resin With Various Polymerization Method
  8. Stimulation Of Osteoblast Activity By Induction Of Aloe Vera And Graft Combination
  9. Plaque Index Between Blind And Deaf Children After Dental Health Education
  10. The Difference Of Dental Anxiety Degree In Children Based On The Frequency Of Dental Appointment
  11. Volatile Sulphur Compounds Elimination: A New Insight In Periodontal Treatment
  12. Piperin And Piplartin As Natural Oral Anticancer Drug

Information DENTJ