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Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 34 / No. 2 / Published : 2001-04

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Original Article :

Potent role of histatin in natural defense system giants oral candidiasis

Author :

  1. Darmawan Setijanto*1
  2. Seicho Makihira*2
  3. Taizo Hamada*3
  1. Department of Public Health, Faculty of Dentistry Airlangga University, Surabaya-Indonesia
  2. Department of Prosthetic Dentistry, Hiroshima University Faculty of Dentistry, Hiroshima, Japan
  3. Department of Prosthetic Dentistry, Hiroshima University Faculty of Dentistry, Hiroshima, Japan

Abstract :

The amergence of drug-resistance strain of candida and the recently antifungal medicine with toxicity need for a new antifungal agent and drugs therapies. Human salivary histatins prosess fungicidal and bactericidal activities. This theoretical analysis aimed to introduce the structure and function of salivary histatins in the relationship with their candidacial activity. The predominant human histatins are histatin-1, histatin-3 and histatin-5. Histatin-5 was the most and histatin–1 was the least effective. Candidacidal active site of histatin-5 was in C-terminal domain comprising of 16 amino acid residues (GYKRKFHEKHHSHRGY). Histatin-5 was superior comparing with recent antifungal agent (azoles-based antifungal), because histatin-5 kills both azoles-sensitive and azoles-resistant strain equally well. This discussion described two concepts of histatin’s candidacidal activity, first, histamine need to be transported into the cell and targeted into the mitochondria and second, histatin-5 induce efflux of cellular ATP through binding to a cell surface component. Although the exact candidacidal mechanism of histatins is still unknown, histatins was proven as a potent in vitro antifungal agent and have promised as therapeutic agents against oral candidiasis. In the application of denture-induced stomatitis, acrylic resin could be surface-modified and loaded with histatin-5 as a mean of controlled release of histatin-5 to an affected area.

Keyword :

histatin, structure, candidacidal,

References :


    Archive Article

    Cover Media Content

    Volume : 34 / No. : 2 / Pub. : 2001-06
    1. Minimal Concentration Of Indonesia Green Tea That Could Inhibit The Growth Of Streptococcus Viridans
    2. Management Iatrogenic Perforation At The Floor Of The Pulp And Root Canal Wall Of The Teeth
    3. The Influence Of The Elon Addition On The Developer Solution Toward The Contrast Of The Dental X-ray Photo
    4. Surgical Treatment On Oronasal Fistulae
    5. Diagnosis Of Radicular Cyst Based On The Quantitative Pattern Of The Five Protein Fractions In The Periapical Fluids
    6. Polymerase Chain Reaction: Concept, Methodology And Application
    7. The Polyester Ebp 2421 Denture Base Endurance To The Penetration Of Drinking Liquid Color
    8. The Quality Of Marginal Adaptation Of The Composites Restored With And Without Acid-etched Technic
    9. Amalgam Containing Fluoride Prevents Secondary Caries
    10. The Fungicidal Effect Of Salvadora Persica Solution Against Candida Albicans On Acrylic Denture Base
    11. Bisecting Technic Radiograph Compared With Bitewing-besecting Combine Technic In Upper Third Molar
    12. Potent Role Of Histatin In Natural Defense System Giants Oral Candidiasis