UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 41 / No. 3 / Published : 2008-07

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Original Article :

Potential role of odontoblasts in the innate immune response of the dental pulp

Author :

  1. Tetiana Haniastuti*1
  1. Oral Biology Department Faculty of Dentistry Gadjah Mada University Yogyakarta - Indonesia

Abstract :

Background: Odontoblasts are the cells lining of tooth’s hard structure at the dentin-pulp border, which become the first cells encountered oral microorganisms entering dentin. However, they do not only form a physical barrier by producing dentin, but also provide an innate immune barrier for the tooth. Purpose: The aim of this review was to discuss the potential role of odontoblasts in the innate immune response of the dental pulp. Rreviews: Recent studies have proven that odontoblasts express toll-like receptors, and capable of producing chemokines (i.e. IL-8, CCL2, CXCL2, and CXCL10), and cytokines (IL-1β and TNF-α) following lipopolysacharide exposure. Thereby odontoblasts are actively participating in the recruitment of immune cells in response to caries–derived bacterial products. Furthermore, odontoblasts also produce antimicrobial peptides (hBD-1, hBD-2, and hBD-3), and transform growth factor β that induce antimicrobial and anti-inflammatory activities. Conclusion: The presence of those innate immune molecules indicates that the nonspecific, natural, and rapidly acting defense may also be an important function of odontoblasts.

Keyword :

odontoblasts, dental pulp, innate immunity,


References :





Archive Article

Cover Media Content

Volume : 41 / No. : 3 / Pub. : 2009-09
  1. Cytotoxicity Test Of 40, 50 And 60% Citric Acid As Dentin Conditioner By Using Mtt Assay On Culture Cell Line
  2. Cytotoxicity Of 5% Tamarindus Indica Extract And 3% Hydrogen Peroxide As Root Canal Irrigation
  3. The Effectiveness Of 0.5–0.7% Tetracycline Gel To Reduced Subgingival Plaque Bacteria
  4. The Profile Of Upper Integument Lip Of Baduy And The Nearby Living Sundanese In South Banten, West Java, Indonesia
  5. Isolation And Identification Of Java Race Amniotic Membrane Secretory Leukocyte Protease Inhibitor Gene
  6. The Role Of Proper Treatment Of Maxillary Sinusitis In The Healing Of Persistent Oroantral Fistula
  7. The Management Of Oral Candidosis In Diabetic Patient With Maxillary Herpes Zoster
  8. Non-invasive Endodontic Treatment Of Large Periapical Lesions
  9. Potential Role Of Odontoblasts In The Innate Immune Response Of The Dental Pulp
  10. The Use Of Bay Leaf (eugenia Polyantha Wight) In Dentistry
  11. Effect Of Various Temperature And Storage Duration On Setting Time Of Orega Sealer

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