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Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 43 / No. 4 / Published : 2010-12

TOC : 6, and page :186 - 189

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Original Article :

Pulp nerve fibers distribution of human carious teeth: an immunohistochemical study

Author :

  1. Tetiana Haniastuti *1
  1. Department of Oral Biology Faculty of Dentistry, Universitas Gadjah Mada Yogyakarta - Indonesia

Abstract :

Background: Human dental pulp is richly innervated by trigeminal afferent axons that subserve nociceptive function. Accordingly, they respond to stimuli that induce injury to the pulp tissue. An injury to the nerve terminals and other tissue components in the pulp stimulate metabolic activation of the neurons in the trigeminal ganglion which result in morphological changes in the peripheral nerve terminals. Purpose: The aim of the study was to observe caries-related changes in the distribution of human pulpal nerve. Methods: Under informed consents, 15 third molars with caries at various stages of decay and 5 intact third molars were extracted because of orthodontic or therapeutic reasons. All samples were observed by micro-computed tomography to confirm the lesion condition 3-dimensionally, before decalcifying with 10% EDTA solution (pH 7.4). The specimens were then processed for immunohistochemistry using anti-protein gene products (PGP) 9.5, a specific marker for the nerve fiber. Rresults: In normal intact teeth, PGP 9.5 immunoreactive nerve fibers were seen concentrated beneath the odontoblast cell layer. Nerve fibers exhibited an increased density along the pulp-dentin border corresponding to the carious lesions. Conclusion: Neural density increases throughout the pulp chamber with the progression of caries. The activity and pathogenicity of the lesion as well as caries depth, might influence the degree of neural sprouting.

Keyword :

Caries, dental pulp, nerve fibers, protein gene product 9.5,

References :

  1. Love RM, (2004). Invasion of dentinal tubules by root canal bacteria. - : Endod Top


Archive Article

Cover Media Content

Volume : 43 / No. : 4 / Pub. : 2010-12
  1. Clinical consideration of thrombocytopenia in children
  2. The increasing of odontoblast-like cell number on direct pulp capping of rattus norvegicus using chitosan
  3. Minor modification of millard surgical technique for correction of complete unilateral cleft lip
  4. Biocompatibility and osteoconductivity of injectable bone xenograft, hydroxyapatite and hydroxyapatite-chitosan on osteoblast culture
  5. Alveolar ridge rehabilitation to increase full denture retention and stability
  6. Pulp nerve fibers distribution of human carious teeth: an immunohistochemical study
  7. The management of dental fracture on tooth 61 in a child with attention deficit hyperactivity disorders
  8. Multidisciplinary management of a mandibular buccal plate perforation
  9. Candida albicans adherence on acrylic resin plates immersed in black tea steeping
  10. A combination of endodontic therapy and root resection in furcation involvement case
  11. interleukin-1β expression among periodontitis patients in surabaya