UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 41 / No. 2 / Published : 2008-04

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Original Article :

Pulp tissue inflammation and angiogenesis after pulp capping with transforming growth factor β1

Author :

  1. Sri Kunarti*1
  1. Department of Conservative Dentistry
    Faculty of Dentistry Airlangga University
    Surabaya - Indonesia

Abstract :

In Restorative dentistry the opportunity to develop biomemitic approaches has been signalled by the possible use of various biological macromolecules in direct pulp capping reparation. The presence of growth factors in dentin matrix and the putative role indicating odontoblast differentiation during embryogenesis has led to the examination on the effect of endogenous TGF–β1. TGF–β1 is one of the Growth Factors that plays an important role in pulp healing. The application of exogenous TGF – β1 indirect pulp capping treatment should be experimented in fibroblast tissue in-vivo to see the responses of inflammatory cells and development of new blood vessels. The increase in food supplies always occurs in the process of inflammation therefore the development of angiogenesis is required to fulfil the requirement. This in-vivo study done on orthodontic patients indicated for premolar extraction between 10-15 years of age. A class V cavity preparation was created in the buccal aspect 1 mm above gingival margin to pulp exposure. The cavity was slowly irrigated with saline solution and dried using a sterile small cotton pellet the sterile absorbable collagen membrane was applied and soaked in 5 ml TGF–β1. It was covered by a Teflon pledge to separate from Glass Ionomer Cement restoration. Evaluation was performed on day 7; 14; and 21. All samples were histopathologycally examined and data was statistically analysed using one way ANOVA and Dunnet T3.There were no inflammatory symptoms in clinical examination on both ca(OH)2 and TGF–β1, but they increased the infiltration of inflammatory cells on histopathological examination. There were no significant differences (p >0.05) between Ca(OH)2 and TGF-1 in inflammation cell and significant differences (p0.05) in inflammation cell with in TGF-1 groups and significant differences (p

Keyword :

calcium hydroxide , TGF-β1, inflammation, angiogenesis ,


References :





Archive Article

Cover Media Content

Volume : 41 / No. : 2 / Pub. : 2008-06
  1. The Role Of Partial Denture In Management Of Hypohidrotic Ectodermal Dysplasia
  2. Management Of Zygomatic-maxillary Fracture (the Principles Of Diagnosis And Surgical Treatment With A Case Illustration)
  3. The Transversal Strength Of Acrylic Resin Plate After Soaking In The Juice Of The Noni Fruit (morinda Citrifolia Linn.)
  4. Pulp Tissue Inflammation And Angiogenesis After Pulp Capping With Transforming Growth Factor β1
  5. The Effect Of Exposure Duration Of Self Etch Dentin Bonding On The Toxicity Of Human Gingival Fibroblast Of Cell Culture
  6. Effect Of Il-1 And Gustducin Expression Change On Bitter Taste During Fever
  7. Differences In Cytotoxicity Between 5% Tetracycline Hydrochloride And 15% Edta As Root Canal Irrigant
  8. The Level Of Streptococcus Mutans And Lactobacillus In Saliva Of Dental Caries And Free Caries Children
  9. Combination Of Natural Teeth And Osseointegrated Implants As Prosthesis Abutments In A Posterior Cantilever Bridge
  10. Students’ Evaluation Of Preclinical Simulation For All Ceramic Preparation (in Faculty Of Dentistry Universiti Kebangsaan Malaysia)
  11. Potency Of Probiotic Therapy For Dental Caries Prevention
  12. The Use Of 90% Aloe Vera Freeze Drying As The Modulator Of Collagen Density In Extraction Socket Of Incicivus Cavia Cobaya

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