UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 39 / No. 4 / Published : 2006-10

Order : 10, and page :172 - 176

Related with : Scholar   Yahoo!   Bing

Original Article :

Roles of secretory leukocyte protease inhibitor amniotic membrane in oral wound healing

Author :

  1. Elly Munadziroh*1
  1. Dosen Fakultas Kedokteran Gigi

Abstract :

Secretory Leukocyte Protease Inhibitor (SLPI) is serine protease inhibitor. Secretory Leukocyte Protease Inhibitor is a protein found in secretions such as whole saliva, seminal fluid, cervical mucus, synovial fluid, breast milk, tears, and cerebral spinal fluid, as in secretions from the nose and bronchi, amniotic fluid and amniotic membrane etc. These findings demonstrate that SLPI function as a potent anti protease, anti inflammatory, bactericidal, antifungal, tissue repair, extra cellular synthesis. Impaired healing states are characterized by excessive proteolysis and often bacterial infection, leading to the hypothesis that SLPI may have a role in the process. The objectives of this article are to investigate the role of SLPI in oral inflammation and how it contributes to tissue repair in oral mucosa. The oral wound healing responses are impaired in the SLPI sufficient mice and matrix synthesis and collagen deposition are delayed. This study indicated that SLPI is a povital factor necessary for optimal wound healing.

Keyword :

Secretory leukocyte protease inhibitor, amniotic membrane, oral wound healing ,


References :

Ashcroft GS,(2000) Secretory leukocyte protease inhibitor mediates non redundant functions necessary for normal wound healing 6(10):1147–53 : Nat Med





Archive Article

Cover Media Content

Volume : 39 / No. : 4 / Pub. : 2006-12
  1. Effectivity Of Blunt End With Side Hole Irrigation Needle To Eliminate Root Canal Bacteria
  2. Prevalence Of Oral Habits In Homeless Children Under Care Of Yayasan Bahtera Bandung
  3. The Effect Of Mastication Muscular Tone On Facial Size In Patients With Down Syndrome
  4. Prevalence Of Hypodontia In Chinese Orthodontic Patients
  5. The Periodontal Pain Paradox: Difficulty On Pain Assesment In Dental Patients (the Periodontal Pain Paradox Hypothesis)
  6. Clinical Application Of The Activity Index To Parameter For Evaluation Of Electromyographic Activity Of The Masticatory Muscles
  7. The Fractographic Analysis Of Three Dentin Bonding Agents On Tooth Surface
  8. The Transverse Strength Of Acrylic Resin After Coleus Amboinicus, Lour Extract Solution Immersion
  9. The Potential Application Of Stem Cell In Dentistry
  10. Roles Of Secretory Leukocyte Protease Inhibitor Amniotic Membrane In Oral Wound Healing

Information DENTJ