UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 45 / No. 2 / Published : 2012-06

Order : 11, and page :114 - 120

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Original Article :

Seroprevalence of herpes simplex virus types 1 and 2 and their association with cd4 count among hiv-positive patients

Author :

  1. Irna Sufiawati*1
  2. Sunardhi Widyaputra*2
  3. Tony S. Djajakusumah *3
  1. Department of Oral Medicine, Faculty of Dentistry, University of Padjadjaran,Bandung - Indonesia
  2. Department of Oral Pathology, Faculty of Dentistry, University of Padjadjaran, Bandung - Indonesia
  3. Department of Dermatology & Venereology, Faculty of Medicine, University of Padjadjaran, Bandung - Indonesia

Abstract :

Background: Herpes simplex virus (HSV) is a common cause of viral opportunistic infections among HIV-positive patients. Frequent, more severe and prolonged episodes of recurrent HSV infection can be a source of significant morbidity and mortality among HIV-positive patients with advanced immunosuppression, reflected by low CD4 count. However, conflicting results have also been reported. Purpose: The aim of this study was to investigate the seroprevalence of HSV type 1 (HSV-1) and type 2 (HSV-2) in HIV-positive patients compare with the rate in HIV-negative patients, and to evaluate their association with CD4 count. Methods: A cross sectional study was conducted among 145 subjects consisting of 80 HIV-positive and 65 HIV-negative patients attending the top referral hospital in Bandung, West Java, Indonesia. The serum obtained was assayed for the presence of HSV-1 and HSV-2 IgG antibodies using ELISA kits. Data were analyzed using a Chi-square test, t-tests and analysis of variance (ANOVA). Results: There were no significant differences in HSV-1 seroprevalence between HIV-positive patients (71%) and HIV-negative patients (66%). HSV- 2 seroprevalence was significantly higher in HIV-positive patients (30%) than HIV-negative patients (5%). The titers of HSV-1 IgG antibodies in HIV-positive patients (mean 24.63 ± 19.06 IDU) were significantly lower than those of HIV-negative patients (mean 44.62 ± 33.22 IDU). In contrast, HSV-2 IgG antibody titers in HIV-positive patients (mean 13.31 ± 20.28 IDU) were significantly higher than HIV-negative patients (mean 4.42 ± 10.99 IDU). There was no significant correlation between HSV-1 and HSV-2 seropositivity and CD4 count among HIV-positive patients. However, most of HSV-2 seropositive patients had CD4 count < 200 cells/mm3. Conclusion: Seroprevalence of HSV-1 and HSV-2 among HIV-positive patients was high with no correlation with CD4 count.

Keyword :

HSV, IgG, HIV, CD4,


References :

Fauci AS,(1993) Immunopathogenesis of HIV infection - : J Acquir Immune Defic Syndr





Archive Article

Cover Media Content

Volume : 45 / No. : 2 / Pub. : 2012-06
  1. The Importance Of Masticatory Functional Analysis In The Diagnostic Finding And Treatment Planning For Prosthodontic Rehabilitation
  2. The Management Of Chronic Traumatic Ulcer In Oral Cavity
  3. Simplified Digital Infra Red Photography: An Alternative Tool In Bitemark Forensic Investigation
  4. The Relation Between Salivary Siga Level And Caries Incidence In Down Syndrome Children
  5. Inhibition Of 10% Alpinia Galanga And Alpinia Purpurata Rhizome Extract On Candida Albicans Growth
  6. Pulpal Inflammation After Vital Tooth Bleaching With 38% Hydrogen Peroxide
  7. The Increasing Of Enamel Calcium Level After Casein Phosphopeptide-amorphous Calcium Phosphate Covering
  8. Cytotoxicity Of Betel Leaf (piper Betel L.) Against Primary Culture Of Chicken Embryo Fibroblast And Its Effects On The Production Of Proinflammatory Cytokines By Human Peripheral Blood Mononuclear Cells
  9. Deoxypyridinoline Level In Gingival Crevicular Fluid As Alveolar Bone Loss Biomarker In Periodontal Disease
  10. Craniofacial Morphology Of Children With Complete Unilateral Cleft Lip And Palate Following Labioplasty And Palatoplasty
  11. Seroprevalence Of Herpes Simplex Virus Types 1 And 2 And Their Association With Cd4 Count Among Hiv-positive Patients

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