UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 41 / No. 4 / Published : 2008-10

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Original Article :

Stimulation of type i collagen activity in healing of pulp perforation

Author :

  1. Sri Kunarti*1
  1. Department of Conservative Dentistry
    Faculty of Dentistry Airlangga University
    Surabaya - Indonesia

Abstract :

Background: TGF-β1 is a connective tissue stimulant, potential regulator for tissue repair, and promoter in wound healing. The healing of pulp perforation is decided by quantity and quality of new collagen deposition. TGF-β1 upregulates collagen transcription. However, after several weeks production of type I collagen synthesis is stopped and enzymatic degradation of collagen matrix will occur. Purpose: Observe synthesis type I collagen during the process of pulp perforation healing in 7, 14, and 21 days after being treated using TGF-β1. Methods: This research in vivo from orthodontic patients indicated for premolar extraction, between ages 10–15 years. A class V cavity preparation was created in the buccal aspect 1 mm above gingival margin until pulp exposure. Cavity was irrigated slowly with saline solution and dried with a sterile small cotton pellet. The sterile absorbable collagen membrane used, soaked with 5 μl of TGF-β1. It was covered by teflon pledge to separate from glass ionomer cement as restoration. Evaluated on day 7th, 14th, and 21st. All samples were extracted and prepared for immunohystochemical examination. Result: Data were analyzed by t-test. There was significant difference in synthesis type I collagen compared between 7–14 days and 7–21 days after treatment by TGF-β1 also Ca(OH)2. There was significant difference compared between TGF-β1 and Ca(OH)2 in 14–21 days after treatment (means TGF-β1 > Ca(OH)2). Conclusion: Elevation of synthesis type 1 collagen by TGF-β1 in 20 mg/ml.

Keyword :

type I collagen, TGF-β1, calcium hydroxide, pulp perforation,


References :





Archive Article

Cover Media Content

Volume : 41 / No. : 4 / Pub. : 2009-12
  1. Effect Of Oxygen Hyperbaric Therapy On Malondialdehyde Levels In Saliva Of Periodontitis Patients With Type 2 Diabetes Mellitus
  2. Reducing Allergic Symptoms Through Eliminating Subgingival Plaque
  3. The Role Of Dentists On Medically Compromised Children’s Oral And Dental Prophylaxis In Hospital
  4. The Surface Roughness Difference Between Microhybrid And Polycrystalline Composites After Polishing
  5. The Relation Of Periodontal Diseases To Systemic Diseases
  6. Delayed Bracket Placement In Orthodontic Treatment
  7. Complex Aesthetic Treatment On Anterior Maxillary Teeth With Malposition
  8. Stimulation Of Type I Collagen Activity In Healing Of Pulp Perforation
  9. The Combination Of Sodium Perborate And Water As Intracoronal Teeth Bleaching Agent
  10. Bootstrap Study To Estimate Linear Regression Parameter (application In The Study On The Effect Of Oral Hygiene On Dental Caries)
  11. Immunodetection Of Rasp21 And C-myc Oncogenes In Oral Mucosal Swab Preparation From Clove Cigarette Smokers

Information DENTJ