UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 46 / No. 3 / Published : 2013-09

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Original Article :

The effect of chitosan gel concentration to neutrophyl and macrophage in gingival ulcer

Author :

  1. Fajar Kumalasari*1
  2. Tasya Adistya*2
  3. Anne Handrini Dewi*3
  4. Mayu Winnie Rachmawati*4
  1. Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta-Indonesia
  2. Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta-indonesia
  3. Departement of Biomedical Dentistry, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta – Indonesia
  4. Departement of Biomedical Dentistry, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta – Indonesia

Abstract :

Bacground: Chitosan is reported as an accelerator of wound healing. Purpose: The aims of this study is to evaluate the effect of chitosan gel concentration toward the neutrophyl and macrophage in gingival ulcer healing process of Sprague Dawley rats. Methods: Twenty subjects were divided into treatment groups, A, B, C which was given 1%, 2% and 3% chitosan gel and group D as control group. The ulcer was made by applicating the 2 x 2 mm2 Whatmann number 1 filter paper which had been soaked into the 98% acetic acid for 5 minutes on the gingival surface below the interdental of the lower incisivus of the rats for 40 seconds. One drop chitosan gel was applicated on the ulcer, twice a day during three days. The subjects were sacrificed and its gingival tissue was taken for histologically processed and stained with hematoxylin eosin. Result: The one way ANOVA test showed that significant difference neutrophyl and macrophage among all of group (p<0.05). The Pearson correlation showed that there is a positive strong correlation (0,979) between chitosan concentration and macrophage density. Chitosan gel with 1%, 2%, and 3% concentration influenced significantly to neutrophyl and macrophage density. The higher concentration can decreased the neutrophil but increased the macrophage because they have antimicrobial activity. Conclusion: These result indicate that the chitosan gel influence both of neutrofil and macrophage in gingival ulcer healing process and chitosan gel 3% has a better effect than 1% and 2% concentration.

Keyword :

Chitosan gel, wound healing, gingival ulcer, neutrophyl, macrophage,


References :

Naldini A,(2005) Role of inf lammator y mediators in angiogenesis - : Current Drug Targets-Inflammation & Allergy





Archive Article

Cover Media Content

Volume : 46 / No. : 3 / Pub. : 2013-09
  1. Correlation Between Salivary Leptin Levels And Incidence Of Caries In Obese Children
  2. The Role Of Calcium On Enamel Hypoplasia Prevention
  3. The Correlation Of Micronucleus Formation And 8-oxo-dg Expression Due To The Panoramic Radiography Exposure
  4. Fluoride Determination Of Children And Adult Toothpaste By Spectrophotometry
  5. Heteroplasmy Analysis Of Dental Pulp Mitochondrial Dna In Forensic Personal Identification
  6. Effect Of Gestational Diabetes Mellitus On The Expression Of Amelogenin In Rat Offspring Tooth Germ
  7. The Effect Of Chitosan Gel Concentration To Neutrophyl And Macrophage In Gingival Ulcer
  8. Epstein-barr Virus (ebv) Dna As Biomaker Of Nasopharyngeal Carcinoma Diagnosis
  9. Metal Crown Restoration With Fiber Post In Young First Permanent Molar
  10. Cranial Size And Cephalic On Index Mentally Retarded 7–12 Years Old Children
  11. Mechanism Of Pomegranate Extract In Killing Malignant Cells In Mice Through Oral Cavity Mucosa Increased Expression Of P53 Wild

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