UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 40 / No. 3 / Published : 2007-07

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Original Article :

The pattern of p53 gene mutations on oral squamous cell carcinoma

Author :

  1. Peter Agus*1
  1. Department of Oral and Maxillofacial Surgery
    Faculty of Dentistry Airlangga University
    Surabaya – Indonesia

Abstract :

Oral squamous cell carcinoma (OSCC) is the result of accumulation genetic lesion and caused by specific mutation in specific key regulation genes. p53 gene is key target specific regulatory genes which function as negative regulators in cell cycle control. The highest mutation rates found in human cancers and the etiology in high risk populations and the pattern of molecular pathogenesis mechanism involved in the OSCC remain unclear. The purpose of this study is to determine the presence of alteration or mutation of p53 gene and to associate these mutations histopathological status of the patients such as well differentiated and poorly differentiated in OSCC in order to elucidate the molecular pathogenesis mechanism of OSCC based on the pattern of p53 gene. Using 40 untreated well and poorly differentiated OSCC biopsy samples and 16 normal patients were analyzed for the presence of mutation in the conserved region of the p53 gene exons 5 and or 7 by PCR-SSCP mutational analysis for p53 gene showed 70% of total samples : exon 5: 27.5% with heterozygous mutation 81.8% , exon 7: 55% with heterozygous mutation 100%. The incidence of p53 mutation was not significantly associated with well and poorly differentiated OSCC with the exception in exon 5 of p53 gene (p = 0.013) using contingency coefficient. This study concludes that mutation of p53 gene especially in exon 7 may not indirectly play in the progressivity of OSCC with the exception of mutation in exon 5 of p53 which indicates the essential role in the progressivity of OSCC.

Keyword :

p53, exon5, exon7, mutation, OSCC, well and poorly differentiated ,


References :





Archive Article

Cover Media Content

Volume : 40 / No. : 3 / Pub. : 2007-09
  1. Sealing Ability Of Hydroxyapatite As A Root Canal Sealer: In Vitro Study
  2. Jaw Locking After Maxillofacial Trauma
  3. New Insight In Pediatric Dentistry: Preventive Dentistry In Allergy Management Protocol
  4. The Pattern Of P53 Gene Mutations On Oral Squamous Cell Carcinoma
  5. The Difference Of Tensile Bond Strength Between Total Etch And Self Etch Dentin Bonding On Dentin Surface
  6. The Microbiological Detection Of Mycobacterium Tuberculosis From Oral Lesion
  7. Antibacterial Force Of The Luting-type Of Glass Ionomer Cement Toward Lactobacillus Species And Streptococcus Mutans
  8. Prevalence Of Xerostomia On Type 2 Diabetes Mellitus In Hajj Surabaya
  9. Accuracy Of A Fourth Generation Apex Locator-an In Vitro Evaluation
  10. The Effect Of Acidulated Phosphate Fluoride Application On Dental Enamel Surfaces Hardness
  11. The Determination Of Phenazone In Blood Plasma For Obtained Sistem Suitable Test Of Monitoring Drug Level

Information DENTJ