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Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 45 / No. 2 / Published : 2012-06

Order : 4, and page :79 - 83

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Original Article :

The relation between salivary siga level and caries incidence in down syndrome children

Author :

  1. Rosdiana*1
  2. Mochammad Fahlevi Rizal*2
  1. Resident at Pediatric Dentistry, Faculty of Dentistry, Indonesia University Jakarta - Indonesia
  2. 2Department of Pediatric Dentistry, Faculty of Dentistry, Indonesia University, Jakarta - Indonesia

Abstract :

Background: Down syndrome or Trisomy 21 is a genetic disorder caused by extra chromosome on chromosome 21. Down syndrome child, however, has good resistance against caries, and some of them even are caries-free. It is because the level of salivary sIgA in Down syndrome children is equal or even higher than that in normal children. Purpose: This review was aimed to review the relation between salivary sIgA level and caries incidence in Down syndrome children. Reviews: Down syndrome is a collection of symptoms caused by chromosomal abnormality that has a number of physical and mental disorders. Down syndrome children, nevertheless, have significantly lower incidence of caries than normal children. These conditions are thought to relate to characteristics of oral cavity and the level of salivary sIgA in Down syndrome children. Caries is a disease of dental hard tissues caused by the fermentation of sucrose into glucans by glucosyltransferase enzymes (GTF) of Streptococcus mutans (S. mutans). One of proteins in saliva that acts as a defense mechanism is imunoglubulin. Secretory immunoglobulin A (sIgA) inhibits the activity of S. mutans as bacteria causing caries forming glucan. This immunoglobulin, sIgA, is the most abundant immunoglobulin in saliva. The level of salivary sIgA in Down syndrome children is significantly higher than that in normal children. Conclusion: Besides factors of tooth eruption delays, wide spaces among teeth, microdontia, pH, and high saliva contents (calcium, sodium, bicarbonate), the low incidence of caries in Down syndrome children is also related with the higher level of salivary sIgA in Down syndrome children than that in normal children.

Keyword :

Down syndrome, sIgA, caries,


References :

Mc Donald RE,(2011) Dentistry for the child and adolescent Missouri : Mosby Inc





Archive Article

Cover Media Content

Volume : 45 / No. : 2 / Pub. : 2012-06
  1. The Importance Of Masticatory Functional Analysis In The Diagnostic Finding And Treatment Planning For Prosthodontic Rehabilitation
  2. The Management Of Chronic Traumatic Ulcer In Oral Cavity
  3. Simplified Digital Infra Red Photography: An Alternative Tool In Bitemark Forensic Investigation
  4. The Relation Between Salivary Siga Level And Caries Incidence In Down Syndrome Children
  5. Inhibition Of 10% Alpinia Galanga And Alpinia Purpurata Rhizome Extract On Candida Albicans Growth
  6. Pulpal Inflammation After Vital Tooth Bleaching With 38% Hydrogen Peroxide
  7. The Increasing Of Enamel Calcium Level After Casein Phosphopeptide-amorphous Calcium Phosphate Covering
  8. Cytotoxicity Of Betel Leaf (piper Betel L.) Against Primary Culture Of Chicken Embryo Fibroblast And Its Effects On The Production Of Proinflammatory Cytokines By Human Peripheral Blood Mononuclear Cells
  9. Deoxypyridinoline Level In Gingival Crevicular Fluid As Alveolar Bone Loss Biomarker In Periodontal Disease
  10. Craniofacial Morphology Of Children With Complete Unilateral Cleft Lip And Palate Following Labioplasty And Palatoplasty
  11. Seroprevalence Of Herpes Simplex Virus Types 1 And 2 And Their Association With Cd4 Count Among Hiv-positive Patients

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