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Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 42 / No. 3 / Published : 2009-07

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Original Article :

The role of  msx1 and pax9 in pathogenetic mechanisms of  tooth agenesis

Author :

  1. Yani Corvianindya Rahayu*1
  2. Dyah Setyorini*2
  1. Departement of Oral Biology
    Faculty of Dentistry University of Jember
    Jember - Indonesia
  2. Departement of Pediatric Dentistry
    Faculty of Dentistry University of Jember
    Jember - Indonesia

Abstract :

Background: Tooth agenesis is one of the most common developmental anomalies in human, which one or a few teeth are absent�t because they have never formed,maycausecosmeticorocclusalharm,whilesevereagenesiswhicharerelativelyrarerequireclinical, may cause cosmetic or occlusal harm, while severe agenesis which are relatively rare require clinical attention to support and maintain the dental function. Molecular studies have demonstrated that tooth development is under strict genetic control. Purpose: This article want to review the genetic regulating that are responsible for tooth agenesis especially  the role of Msx1 and Pax9 in pathogenetic mechanisms of   tooth agenesis. Rreview:: Toothagenesisisaconsequenceofaqualitativelyorquantitativelyooth agenesis is a consequence of a qualitatively or quantitatively impaired function of genetic networks, which regulate tooth development. Mutations in Msx1 and Pax9  genes are dominant for tooth agenesis in humans. The Pax9 gene, which codes for a paired domain-containing transcription factor that plays an essential role in the development of mammal dentition, has been associated with selective tooth agenesis in humans and mice. Conclusion: Reduced amount of functional Msx1 or Pax9 protein in the tooth forming cells is able to cause severe and selective tooth agenesis. There are differences in the frequency of agenesis of specific teeth associated with the defects in Msx1 and defects in Pax9.

Keyword :

tooth agenesis, genetic regulation, pathogenetic mechanisms, Msx1, Pax9,

References :


    Archive Article

    Cover Media Content

    Volume : 42 / No. : 3 / Pub. : 2009-09
    1. Treatment Of Recurrent Aphthous Stomatitis Major With Metronidazole And Ciprofloxacin
    2. Mechanical Properties Of Carving Wax With Various Ca-bentonite Filler Composition
    3. Immunoglobulin-g Level On Aggressive Periodontitis Patients Treated With Clindamycin
    4. Color Stability Of Visible Light Cured Composite Resin After Soft Drink Immersion
    5. Storage Duration Effect On Deformation Recovery Of Repacked Alginates
    6. The Influence Of Xylitol Containing Toothpaste On Plaque Formation Inhibition On Fixed Bridge
    7. Functional Relationship Of Room Temperature And Setting Time Of Alginate Impression Material
    8. The Role Of  Msx1 And Pax9 In Pathogenetic Mechanisms Of  Tooth Agenesis
    9. The Use Of Holmium-yttrium Aluminum Garnet Laser As Pit And Fissure Cleaner