UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 45 / No. 4 / Published : 2012-12

Order : 1, and page :181 - 186

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Original Article :

The role of actinobacillus actinomycetemcomitans fimbrial adhesin on mmp-8 activity in aggressive periodontitis pathogenesis

Author :

  1. R ini Devijanti Ridwan *1
  1. Department of Oral Biology Faculty of Dentistry, Universitas Airlangga, Surabaya – Indonesia

Abstract :

Background: Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) is Gram negative and a major bacterial agent associated with aggressive periodontitis in young adult, this bacteria was an important factor in pathogenesis of aggressive periodontitis. A. actinomycetemcomitans possesses fimbriae with an adhesin protein that was the first bacterial molecules to make physical contact with host. Purpose: The objective of this research was to analyzed the influence of A. actinomycetemcomitans fimbrial adhesin protein induction againts MMP-8 activity. Methods: The research was an experimental laboratory study, the step in this study was isolation and identification A. actinomycetemcomitans, characterize A. actinomycetemcomitans adhesin and study the role of A. actinomycetemcomitans adhesin in Wistar rats. Results: The result of this research on the role of adhesin in Wistar rats after analysis with Analysis of Variance (ANOVA) showed significant differences in the control group with group induction with A. actinomycetemcomitans, A. actinomycetemcomitans plus adhesin and adhesin. MMP-8 activity increased with induction A. actinomycetemcomitans and 24 kDa A. actinomycetemcomitans adhesion. This fimbrial adhesin protein showed that A. actinomycetemcomitans has the ability to adhesion, colonization and invasion for host in aggressive periodontitis pathogenesis. Conclusion: A. actinomycetemcomitans fimbrial adhesin protein has a role in increasing MMP-8 activity for aggressive periodontitis pathogenesis.

Keyword :

A. actinomycetemcomitans, adhesin, MMP-8, aggressive periodontitis,


References :

Velden V,(2006) Java project on periodontal diseases. The natural development of periodontitis: risk factor, risk predictors and risk determinants - : Clin Periodontol





Archive Article

Cover Media Content

Volume : 45 / No. : 4 / Pub. : 2012-12
  1. The Role Of Actinobacillus Actinomycetemcomitans Fimbrial Adhesin On Mmp-8 Activity In Aggressive Periodontitis Pathogenesis
  2. Aesthetic Treatment On Anterior Teeth Crown Fracture Caused By Dental Trauma
  3. Molecular Characterization Of Interleukin-1a (+4845) Gtgene In Aggresive Periodontitis Patients
  4. Antitumor Activity Of Intratumoral Injection Of Pcdna3.1-p27kip1mt Followed By In Vivo Electroporation In A Malignant Burkitt’s Lymphoma Cell Xenograft
  5. The Effect Of Nickel As A Nickel Chromium Restoration Corrosion Product On Gingival Fibroblast Through Analysis Of Bcl-2
  6. Inhibition Of Dental Plaque Formation By Toothpaste Containing Propolis
  7. Inhibition Effect Of Cashew Stem Bark Extract (anacardium Occidentale L.) On The Inhibition Of Biofilm Formation Of Streptococcus Sanguinis
  8. Antibacterial Efficacy Of Salvadora Persicaas A Cleansing Teeth Towards Streptococcus Mutansand Lactobacilli Colonies
  9. Pomegranate Juice As An Ideal Mouthrinse For Fixed Orthodontic Patients
  10. The Increasing Of Fibroblast Growth Factor 2, Osteocalcin, And Osteoblast Due To The Induction Of The Combination Of Aloe Vera And 2% Xenograft Concelous Bovine
  11. The Ph Changes Of Artificial Saliva After Interaction With Oral Ph Changes Of Artificial Saliva After Interaction With Oral Changes Of Artificial Saliva After Interaction With Oral Micropathogen

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