UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 46 / No. 1 / Published : 2013-03

Order : 4, and page :14 - 17

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Original Article :

The role of inducible nitric oxide synthase in teeth periapical lesions immunopathogenesis caused by enterococcus faecalis

Author :

  1. Tamara Yuanita*1
  2. Latief Moduto*2
  3. Kuntaman*3
  1. Department of Conservative Detistry, Faculty of Dentistry, Universitas Airlangga, Surabaya - Indonesia
  2. Department of Conservative Detistry, Faculty of Dentistry, Universitas Airlangga, Surabaya - Indonesia
  3. Faculty of Medicine, Universitas Airlangga, Surabaya - Indonesia

Abstract :

Background: Periapical lesions, are characterized by an immune response to the invading bacteria consequences periapical bone destruction. In root canal treatment failure was found Enterococcus faecalis (E. faecalis) as most species. iNOS found an important role in protection against infection, plays vital roles in fighting pathogens and contributing to disease pathology. Purpose: This study was to observed the role of iNOS in teeth periapical lessions immunopathogenesis caused by E. faecalis. Methods: The randomized post-only control group design used in this study, This study used 24 Wistar rats, were divided into three groups (each group consisted of 8 rats), as negative controls group is a normal teeth, in the positive controls group was made by drilling the upper right first molar to penetrate the dental pulp and was induced with 10μl BHI-b then filled with Glass Ionomer Cement (GIC) and the treatment group, after drilling the teeth, then inoculated with E faecalis ATCC 29212 106 CFU into 10μl BHI-b then filled with GIC to prevent contamination. It takes 21 days to get periapical lesions and rat were sacrificed, and then the expression of iNOS was measured. Results: Statistical analysis using Anova found a significant differenced between control and treatment groups (p<0.05). Conclusion: This study concluded that INOS role in teeth periapical lesions immunopathogenesis caused by Enterococcus faecalis.

Keyword :

Enterococcus faecalis, inducible Nitric Oxide Synthase (iNOS), periapical lesions,


References :

Kayaoglu G,(2004) Virulence factors of Enterococcus faecalis: Relationship to endodontic disease - : Crit Rev Oral Biol Med





Archive Article

Cover Media Content

Volume : 46 / No. : 1 / Pub. : 2013-03
  1. Patient’s Expectation On Communication Performances Community Of Dental Health Services Providers Located In Urban And Rural Area
  2. Changes In Setting Time Of Alginate Impression Material With Different Water Temperature
  3. Bactericidal And Cytotoxic Effects Of Erythrina Fusca Leaves Aquadest Extract
  4. The Role Of Inducible Nitric Oxide Synthase In Teeth Periapical Lesions Immunopathogenesis Caused By Enterococcus Faecalis
  5. Antitumor Activity Of Antisense Oligonucleotide P45skp2 In Soft Palate Carcinoma Cell Squamous In Vitro
  6. Evaluation Of Local Muscle Soreness Treatment With Anterior Bite Splint Made Of Soft Putty Impression Material
  7. Unidentified Angular Recurrent Ulceration Responsive To Antiviral Therapy
  8. The Inhibition Of Malignant Epithelial Cells In Mucosal Injury In The Oral Cavity Of Strains By Pomegranate Fruit Extract (punica Granatum Linn) Through Bcl-2 Expression
  9. Shear Strength Of Orthodontic Bracket Bonding With Gic Bonding Agent After The Application Of Cpp-acpf Paste
  10. Hemolysin Activities As Virulence Factor Of Enterococcus Faecalis Isolated From Saliva And Periapical Abscess (gene Detection By Pcr)
  11. Effect Of Citrus Aurantifolia Swingle Essential Oils On Methyl Mercaptan Production Of Porphyromonas Gingivalis Triggering Halitosis

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