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Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 44 / No. 3 / Published : 2011-09

TOC : 1, and page :117 - 121

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Original Article :

The role of probiotic on alveolar bone resorption

Author :

  1. Desi Sandra Sari*1
  2. Zahara Meilawaty*2
  3. M. Nurul Amin*3
  1. Department of Periodontics, Faculty of Dentistry, Jember University Jember - Indonesia
  2. Department of Biomedicine Faculty of Dentistry, Jember University Jember - Indonesia
  3. Department of Biomedicine Faculty of Dentistry, Jember University Jember - Indonesia

Abstract :

Background: Probiotics are microbes derived from the group of lactic acid bacteria that work to maintain the health of hosts. Probiotics can also be used to improve oral health. Periodontal disease is usually marked with gingival inflammation and alveolar bone resorption. Gram negative anaerobic bacteria that play important role in human periodontal disease are Porphyromonas gingivalis. (P. gingivalis). P. gingivalis is a virulent bacteria in vivo or in vitro, and mostly found in subgingival plaque of periodontitis patients. Purpose: This study is aimed to know the role of probiotics to inhibit the resorption of alveolar bone induced with P. gingivalis. Methods: This study used male wistar rats divided into 4 groups. Group I was control group (without treatment); group II was induced with P. gingivalis ATCC 33277 for 5 days; group III was induced with P. gingivalis ATCC 33277 and also injected with probiotics (Lactobacillus casei ATCC 4224) for 5 days simultaneously; and group IV was induced with P. gingivalis ATCC 33277 for 5 days and also injected by probiotics (Lactobacillus casei ATCC 4224) in the next 5 days. After that, the samples were decapitated, taken their alveolar bone, and then were examined by immunohistochemistry to observe osteoclast activity in alveolar bone resorption by using tartrate-resistant acid phosphatase (TRAP) expression. All data were then analyzed statistically. Results: It is known that there were significant differences of TRAP expression among all those treatment groups (p < 0.05). Conclusion: It then can be concluded that probiotics can decrease osteoclast activity in periodontal tissue of wistar rats, so it can inhibit alveolar bone resorption.

Keyword :

Probiotics, Porphyromonas gingivalis, Lactobacillus casei, tartrate-resistant acid phosphatase, osteoclast,


References :

  1. Novak KF, (2006). Aggressive periodontitis in clinical periodontology. Philadelphia : WB Saunders


   


Archive Article

Cover Media Content

Volume : 44 / No. : 3 / Pub. : 2011-09
  1. The role of probiotic on alveolar bone resorption
  2. Dental measurements of deuteromalayid javanese students of the faculty of dentistry airlangga university
  3. Recent pharmacological management of oral bleeding in hemophilic patient
  4. Treatment of lingual traumatic ulcer accompanied with fungal infections
  5. The effectiveness of nigella sativa seed extract in inhibiting candida albicans on heat cured acrylic resin
  6. Efficacy of various topical agents to prevent enamel demineralization
  7. Threshold value of enamel mineral solubility and dental erosion after consuming acidic soft drinks
  8. Anterior makeover on fractured teeth by simple composite resin restoration
  9. Management of horizontal crown fracture caused by traumatic injury with endorestoration treatment
  10. Sensitivity difference of streptococcus viridans on 35% piper betle linn extract and 10% povidone iodine towards recurrent apthous stomatitis
  11. Odontoblast layer structure alteration as a response to carious lesions