UNIVERSITAS AIRLANGGA



Detail Article

Journal Of Emergency

ISSN 2301-7864

Vol. 3 / No. 1 / Published : 2014-06

Order : 3, and page :14 - 19

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Original Article :

The effect of amnion freeze-drying to prevent adhesion in rabbit tendon achilles healing

Author :

  1. Prof. M. Sjaifuddin Noer, dr, Sp.B, SpBP-RE (K)*1
  2. Franky Prilyanda, dr*2
  1. Dosen Fakultas Kedokteran
  2. Mahasiswa Fakultas Kedokteran

Abstract :

Background: The main aim of tendon surgery is to restore preserves tendon gliding. The formation of peritendinous adhesion around the repair site is one of several adverse event that may prevent achievement of this aim. The freeze - drying amniotic derives from the fetal membranes which consist of two layers that may have a function as a barrier in the formation of peritendinous adhesion, rich of collagent, accelerate the epitelization and preventing fibrotic tissue formation. Those content of the amniotic membrane could prevent the formation of peritendinous adhesion in tendon healing. The role of freeze – drying amniotic membrane was investigated in rabbit with regard to the prevention of adhesion formation following Achilles tendon repair.   Objective: The objective of this study was to investigate the use of freeze - drying amniotic membrane as a long-term bioprosthesis in hand surgery   Design: Experimental research   Methods: The experimental research  use 32 New Zealand rabbits, devided into two groups. On all group, one of the Achilles tendon was sharply devided, group I was treated by Freeze-drying amniotic, and group II was not treated Freeze-drying amniotic (control). After ten days, the animal were killed, and phatology anatomy examination was done on therepair site. The adhesion was assessed under light microscope with see the number of fibroblast.   Results: Histologic examination demonstrated that use of the freeze – drying amniotic membrane significantly reduced the amount of adhesion compared with the other groups . 10 day after implantation no remnants of freeze – drying amniotic membrane could be identified at the tendon repair site.   Conclusions: Freeze–drying amniotic membrane decrease the amount of fibroblast in tendon repair wound. It’s use in the prevention the adhesions of tendons.

Keyword :

Flexor tendon , Repair, Reconstruction, Adhesion, Freeze–drying Amniotic membrane,


References :

Archauer, MB,(1995) Tendon, in Plastic Surgery Indication Operation and Outcomes 368-83 : Mosby





Archive Article

Cover Media Content

Volume : 3 / No. : 1 / Pub. : 2014-06
  1. Role Of Keratinocyte Progenitor Adipose Derived Stem Cells In The Epithelialization Of Skin Wound Healing In Rabbits
  2. Effect Of Oral Pomegranate (punica Granatum) Peel Aqueous Extract On Macrophage, Fibroblast And Collagen Thickness In Burn Wound Healing
  3. The Effect Of Amnion Freeze-drying To Prevent Adhesion In Rabbit Tendon Achilles Healing
  4. The Comparation Of The Use Of Multifilament Polyglycolide And Polyglyconate (barbed Suture) In Small Intestine Anatomosis With The One Layer Continous Technique
  5. Intraperitoneal Adhesion Prevention With An Intramuscular Injection Of Diphenhydramine Perioperative
  6. Blood Pressure And Pulse Rate Of Severe Preeclampsia S Receiving Magnesium Sulfate And Undergoing Cesarean Section Under General Anesthesia
  7. Clinical And Laboratory Profiles Relationships Of Preeclampsia-eclampsia Patients With Maternal Mortality In The Dr. Soetomo Hospital Surabaya
  8. The Difference Of Internal Diameter Of The Ring On Reponible Lateral Inuinal Hernia With Incarserated Lateral Inguinal Hernia On Children

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