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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 2 / Published : 2015-04

TOC : 12, and page :137 - 141

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Original Article :

Acetosal resistance in coronary artery disease between and within type 2 diabetes mellitus patients

Author :

  1. Ari Yunita K*1
  2. Suharjono*2
  3. Mohammad Yogiarto*3
  4. Bambang SZ*4
  1. Mahasiswa Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Kedokteran
  4. Dosen Fakultas Farmasi

Abstract :

Acetosal reduces the odds of an arterial thrombotic event in high risk patients. However, 10%-20% of patients with an arterialthrombotic event who are treated with acetosal have a recurrent arterial thrombotic event during long-term follow up. Acetosalresistance has been described in some patient populations such as those with an acute coronary syndrome, ischemic stroke, andpercutaneous coronary intervention with drug-eluting stent, stent re-stenosis, and Type 2 Diabetes Mellitus. Patients were dividedinto two groups of ten patients each, 10 patients Coronary Artery Diseases with Type 2 Diabetes Mellitus and 10 patients non-Type 2Diabetes Mellitus. The sampling of this cross sectional study was conducted at departement of Cardiology Dr. Soetomo HospitalSurabaya during July-August 2014. Data from 20 patients were analyzed after exclusion due to protocol violations. All subjects wereon Asetosal 100 mg/day. Four (40%) patients with Type 2 Diabetes Mellitus were acetosal non-responders, acetosal resistance wasobserved in 3 (30%) of nondiabetic patients (p=1.000). In conclusion, no difference has been found on acetosal resistance incoronary artery disease patients with or without Type 2 Diabetes Mellitus. (FMI 2015;51:137-141)

Keyword :

Asetosal Resistance, Type 2 Diabetes Mellitus, Coronary Artery Disease,

References :

  1. Ariturk Z, Islamoglu Y, Gündüz E, Yavuz C, Cil H, Tekbas E, Soydinc S, Kaya H, Elbey MA , (2012). Effect of hypoglycemic drugs on aspirin resistance in patients with diabetes mellitus. 16, 617-621 : Eur Rev Med Pharmacol Sci
  2. Mosorjakova D, Paluch Z, Alusik S , (2007). Aspirin resistence. 108, 7-13 : Bratisl Lek Listy


Archive Article

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Volume : 51 / No. : 2 / Pub. : 2015-04
  1. Implementation of pharmaceutical care in resolving drug problems in type 2 diabetes mellitus
  2. Comparison of the effect of statin types on the reduction of lipid profile and hs-crp inflammatory marker in diabetics with dyslipidemia
  3. Ciprofloxacin is effective in benign prostatic hyperplasia (bph) patients with urethral catheters
  4. Procalcitonin as biomarker of antibiotic effectivity in communityacquired pneumonia
  5. Effect of fursultiamine supplementation on left ventricular ejection fraction (lvef) in grade iii – iv heart failure patients
  6. Diagnostic value of st2 in patients with acute myocardial infarction
  7. Molecular analysis of rpob gene of mycobacterium tuberculosis in patients with suspected pulmonary tuberculosis in surabaya
  8. Liver function tests of patients with dengue fever, dengue hemorrhagic fever and dengue shock syndrome in tropic and infectious disease ward in the department of internal medicine, dr. soetomo hospital, surabaya
  9. Case report: dengue fever with perimyocarditis
  10. Correlation between heat shock protein (hsp) 70 level and left ventricular dysfunction and its effect on cardiovascular and rehospitalization incidence in patients with acute coronary syndrome
  11. Effect of tomato (lycopersicum commune) juice on vaginal wall elasticity in menopausal rats
  12. Acetosal resistance in coronary artery disease between and within type 2 diabetes mellitus patients
  13. Immunochromatography method for rotavirus detection provides good accuracy in diagnosis of rotavirus diarrhea in children