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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 3 / Published : 2014-07

TOC : 11, and page :191 - 196

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Original Article :

Analysis of complicated factors affecting therapy effectiveness in urinary tract infections

Author :

  1. Mirza Junando*1
  2. Achmad Taruna*2
  3. Didik Hasmono*3
  1. Department of Pharmacy, Dr. H. Abdul Moeloek Hospital, Lampung
  2. Nephrology and Hipertension Division, Internal Departemen, Dr. H. Abdul Moeloek Hospital, Lampung
  3. Dosen Fakultas Farmasi

Abstract :

Based on host factors and bacterial causes of infection, urinary tract infection (UTI) can be divided into complicated andnoncomplicated UTI. Complicated UTI are infection with structural and functional urinary tract abnormality, or infection withcomorbid conditions that may extend the therapeutic time and have a high risk of treatment failure, such as UTI with indwellingurinary catheter, chronic kidney disease and diabetes mellitus. This study was to determine antibiotics susceptibility pattern ofisolated microorganism from UTI and to analyze the impact of complicated factor on UTI therapy effectiveness associated withpatient’s clinical and laboratory response. This study was a descriptive analytic observational cohort-prospective study conducted atDr. H. Abdul Moeloek Hospital, Lampung, from November 2013 to January 2014. The mid stream urine specimens of initiallyhospitalization patients were collected based on urinalysis result for bacterial culture and antibiotics susceptibility test according toCLSI. Clinical and laboratory response improvements were assessed since the first admission day and until the patient improved.Thirty five patients with complicated UTI were sampled, but only thirty met the inclusion criteria. Whereas, five patients’ bacteriadata, which cause infection and antibiotical susceptibility, were still taken. The most frequently isolated gram-negative bacteria wasEschericia coli (37%) and gram-positive bacteria was Staphylococcus sp. (11%). In conclusion, antibiotics with the potential of morethan 60% are amoxicillin-clavulanic acid, amikacin and meropenem. There was no significance effect between single complicatedUTI; between single and combined complicated UTI with therapeutic effectiveness (p > 0,05). (FMI 2014;50:191-196)

Keyword :

Complicated urinary tract infection, urinary cathether, diabetes mellitus, chronic kidney disease, amoxycillin-clavulanic acid,

References :

  1. Hooton TM, (2000). Pathogenesis of urinary tract infections: an update. 46, 1-7 : J Antimicrob Chemother
  2. Samirah, Darwati, Windarwati, Hardjoeno, (2006). Pola dan sensitivitas kuman di penderita infeksi saluran kemih. 12, 110-113 : Ind Jour of Clin Path and Med Lab


Archive Article

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Volume : 50 / No. : 3 / Pub. : 2014-07
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  11. Analysis of complicated factors affecting therapy effectiveness in urinary tract infections
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