Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 2 / Published : 2014-04

Order : 9, and page :104 - 109

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Original Article :

Antibiotics quantity-based escherichia coli resistance pattern in patients at surgical and psychiatric wards, dr soetomo hospital, surabaya

Author :

  1. Rebekah Juniati Setiabudi*1
  2. Kuntaman*2
  3. Iva Puspitasari*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

The use of antibiotics is the most common cause of resistance of microorganisms through selective receiver pressure. Individualsdose antibiotic therapy will change the normal microbial flora populations. Antibiotic resistance against gram positive and gramnegative is proliferating around the world. This study aimed to determine the effect of antibiotic use on resistance quantity of normalintestinal microflora of patients in psychiatric inpatient wards and surgery, Hospital Dr. Soetomo. This study was an observationalanalytic cross-sectional design. The study was conducted from April to July 2010. Population is all adult patients whose rectal swabout of a hospital intensive care and psychiatric care spaces in RSUD.Dr. Soetomo. In this study, samples were taken with consecutivesampling method. We identify the intestinal microflora with selective differential medium McConkey, followed IMViC biochemicaltests, and test the sensitivity of the intestinal microflora by antibiotic disc diffusion method on Muller Hinton medium. Antibioticswere tested, namely ceftriaxone, cefotaxime, meropenem amikacin, tetracycline, ampicillin and ciprofloxacin, showed a highsensitivity of the range of 64.4% to 100%. Calculations show that a very significant proportion of resistance to the drug being testedon the numbers p=0.000 to 0.008. Resistance patterns of intestinal microflora in surgical inpatient unit to cefotaxime, ceftriaxone,ampicillin, tetracycline and ciprofloxacin, respectively for 75%, 70%, 97.5%, 82.5% and 70%, while sensitive and meropenemrespectively amiksin - contributed by 67.5% and 100%. Quantity is the highest use of antibiotics ceftriaxone for DDD 362g withDDD/100 patient day is 31.2069 of the number of 40 patients. (FMI 2014;50:104-109)

Keyword :

Escherichia coli, resistance, antibiotics, cefotaxim, sefotaksim,

References :

Agtini MD, Soeharno R, Lesmana M, Punjabi NH, Simanjuntak C, Wangsasaputra F, Nurdin D, Pulungsih SP,(2005) The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance - : BMC Infectious Diseases

Alberti C, Brun-Buisson C, Burchardi H, Martin C, Goodman S, Artigas A, Sicignano A, Palazzo M, et a,(2002) Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study - : Intensive Care Med

Archive Article

Cover Media Content

Volume : 50 / No. : 2 / Pub. : 2014-04
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