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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 42 / No. 1 / Published : 2006-01

TOC : 4, and page :22 - 27

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Original Article :

Antimicrobial activities of andrographolide and propolis against intracellular mycobacterium tuberculosis phagocytosed by monocytes derived macrophages

Author :

  1. Manik R Wahyunitisari*1
  2. Ni Made Mertaniasih*2
  3. Dian Rachmawati*3
  1. Department of Microbiology, Airlangga University School of Medicine
  2. Department of Microbiology, Airlangga University School of Medicine
  3. Department of Microbiology, Mulawarman University School of Medicine

Abstract :

One of the major health problems worldwide is Tuberculosis (TB). According to WHO report, Indonesia has the third highest TB prevalence. Due to the fact of multidrug resistance, there is an urgent need for more potent antibiotics and other drugs. Natural products have been regarded as one of the most successful strategies for creating new medicines. The plant andrographolide and propolis is a superb immune system enhancer in TB, and might be more effective when combined to achieve an higher effect. Macrophages are central effector cells of host defence mechanisms against mycobacteria. However, M. tuberculosis uses macrophages as its preferred habitat. It is not much known how macrophages either kill M. tuberculosis or become its breeding ground. In the present study we investigated the costimulant action of Andrographis paniculata and propolis associated with bactericidal activity on macrophages. Incubation of monocytes derived macrophages of healthy participants with the extract of A. paniculata and propolis activated bactericidal activity against intracellular Mycobacterium tuberculosis, but no significant effect on the macrophages of tuberculosis patient. These findings suggest that andrographolide and propolis may have a limited effect on bactericidal activity in tuberculosis patient.

Keyword :

andrographolide, propolis, macrophages, tuberculosis,


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Archive Article

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Volume : 42 / No. : 1 / Pub. : 2006-01
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