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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 1 / Published : 2015-01

TOC : 1, and page :1 - 6

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Original Article :

Bacterial and antibiotics sensitivity pattern in neonatal sepsis patients

Author :

  1. Anak Agung Ayu Prithadewi*1
  2. Didik Hasmono*2
  3. Dewa Made Sukrama*3
  4. Wayan Dharma Artana*4
  1. Mahasiswa Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Department of Clinical Microbiology Sanglah Hospital, Denpasar
  4. Department of Child Health, Sanglah Hospital, Denpasar

Abstract :

Neonatal sepsis is defined as the presence (probable or documented) of infection together with systemic manifestations of infectionwhich occur in the first month of life. Sepsis in the newborn is still a problem in new baby’s care and service. The delayed,inappropriate, and ineffective antibiotics therapy will increase mortality and associated with decreased survival rates and also as amajor factor contributing to the development of antibiotic resistance. The high frequency of resistance raises awareness in the use ofantibiotics effectively, that is the selection of appropriate antibiotics. Antibiogram can assist in the determination of appropriateempirical antibiotic early, but because antibiogram changed is based on the time and extent of the use of antibiotics, so thatantibiogram must be made periodically and routinely. The purpose of this study was to identify bacterial pattern, bacterial sensitivitypattern in neonatal sepsis patients. A retrospective cohort analysis was carried out in the NICU Sanglah Hospital. Data wascollected from January to June 2013. Bacterial pattern and bacterial sensitivity pattern were identified based on the results ofculture test and sensitivity test. From January to June 2013, the most frequently isolated microorganism was negative-gram bacteria,mostly Serratia marcescens (20%) and Klebsiella oxytoca (20%). Ampicillin and gentamicin which are used to be first line empiricaltherapy on neonatal sepsis was already resistant to most of bacteria. In conclusion, antibiotics piperacillin-tazobactam, meropenem,ertapenem, amikacin and levofloxacin still have good sensitivity for most of bacteria. (FMI 2015;51:1-6)

Keyword :

neonatal sepsis, antibiotics, bacterial pattern, sensitivity bacterial pattern,


References :

  1. Bizzarro MJ, Raskind C, Baltimore RS, Gallagher PG , (2005). Seventy-five years of neonatal sepsis at Yale: 1928-2003. 116, 595-602 : Pediatrics
  2. Chu A, Hageman JR, Schreiber M, Alexander K , (2012). Antimicrobial therapy and late onset sepsis. 13, 94-102 : Neoreviews


   


Archive Article

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Volume : 51 / No. : 1 / Pub. : 2015-01
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