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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 48 / No. 2 / Published : 2012-04

TOC : 1, and page :43 - 49

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Original Article :

Blood glucose reduction in mice (mus musculus) resulting from the administration of pare (momordica charantia) fruit flesh juice

Author :

  1. Sudarno*1
  2. Achmad Basori*2
  3. Jessica Hoetama Jaya*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Mahasiswa Fakultas Kedokteran

Abstract :

Diabetes mellitus is a degenerative disease characterized by blood glucose levels that exceed the normal values for blood glucose that cannot be used by the body. Antidiabetics, such as Metformin, is a current of therapy, but it is associated with diarrhea, dyspepsia, and lactic acidosis. Pare or bitter melon (Momordica charantia) contains charantin that has a function similar to Activator Adenosin 5-monophosphate activated protein kinase (AMPK) and glucose transporter type 4 (GLUT4), so it can be an alternative solutions to reduce blood glucose concentration. The purpose of this study was to compare the fruit pare (Momordica charantia) and metformin effects to reduce concentration of blood glucose in mice (Mus musculus L.). This research used 35 male mice (Mus musculus L.) aged 2 until 3 months and weighed 20 until 30 grams. This study used complete randomize controlled post test design. Mice were grouped into 7 groups. Group I was treated with distilled water (control); group II with Metformin 0.065 mg/g BW; group III with Metformin 0.0325 mg/g BW; group IV with Metformin 0.013 mg/g BW; group V was with Bitter Melon juice in a concentrate of 100%; group VI with Bitter Melon juice in a concentrate of 50%; and group VII with bitter melon juice in a concentrate of 25%. Blood glucose was measured by cutting off 1 cm segment of the tail tip with a scalpel and measured with glucosemeter. The result of this study showed there was no significant difference between the variance (p > 0.05), which might result from the way to extract charantin from the bitter melon. (FMI 2012;48:43-49)

Keyword :

diabetes mellitus, metformin, bitter melon, blood glucose concentration,


References :

  1. Miya TS, (1973). Laboratory Guide in Pharmacology, 4th ed. Minneapolis : Burgess Publishing Company
  2. Lola MHC, Liben P, Soemartojo J, (2008). Efek kombinasi jus daging buah pare (Momordica charantia L.) dan jus umbi bawang putih (Allium sativum L.) terhadap penurunan kadar glukosa darah. - : Jurnal Obat Bahan Alam


   


Archive Article

Cover Media Content

Volume : 48 / No. : 2 / Pub. : 2012-04
  1. Blood glucose reduction in mice (mus musculus) resulting from the administration of pare (momordica charantia) fruit flesh juice
  2. Effect of reprocessing cellulose dialyzer substituted with the product r-hydrogen peroxide to clearance urea dialyzer in chronic hemodialysis patient
  3. Soot particulate exposure increases cd54/intercellular adhesion molecule-1 (icam-1) expression in cardiovascular disorder
  4. Red yeast rice (monascus purpureus) extract increases interleukin-2 level in dengue infection patients
  5. Effects of zinc on different nutrition improvement status in hiv/aids patient
  6. The intestinal cryptosporidiosis in hiv/aids patients who have homosexual behaviour
  7. Characteristics of hiv-positive pregnant women in dr. soetomo hospital, surabaya
  8. Personality affects depression occurrence in hiv/aids patient
  9. Heating therapy lowers blood glucose level in mice (mus musculus)