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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 1 / Published : 2008-01

TOC : 11, and page :52 - 55

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Original Article :

Bone morphogenetic protein 4 (bmp4) and prostaglandin alpha (pge2α) molecular expression in healing process acceleration of long bone shaft fracture using immediate repetitive axial compression tension stabilization (ireact)

Author :

  1. Achmad Sjarwani*1
  1. Department of Orthopaedics, Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Jl Prof Dr Moestopo 6-8, Surabaya

Abstract :

Bone morphogenic proteins (BMPs) play central roles in differentiation, development, and physiologic tissue remodeling. Prostaglandins are potent regulators of bone formation and bone resorption that can have both stimulatory and inhibitory effects. Here we present a novel mechanism for the inhibitory effect of estrogens on BMP2 function on acceleration of healing Process of long bone shaft fracture by Immediate Repetitive Axial Compression Tension Stabilization (IREACT). Male adult goats (fractured, Reposition-fixation, IREACT), 6 months of age were used in the study. Bone Morphogenetic Protein 4 (BMP 4) and that PGE2 were determined by immunohistochemistry technique and ELISA. Sample research are bone tissue and plasma that prepared from immediate and repetitive loading (IREACTS) compared to fracture without loading. The result showed that healing process occur more rapidly on immediate and repetitive loading (IREACTS) compared to fracture without loading based on the expression of BMP-4 and that PGE2 of bone tissues and serum. In this studies resulted that PGE2 have been shown to inhibit osteoblasts by repressing BMP 4 production. The result also indicated that prostaglandins are involved in the response of bone tissue and cells to mechanical stress. In conclusion, ER and BMP-4 have key roles in the mechanism to achieve bone healing.

Keyword :

IREACT, PGE2 , BMP-4,


References :

  1. Jee, WS & Ma, YF, (1997). In vivo anabolic actions of prostaglandins in bone . - : Bone (NY)
  2. Keila, S, Kelner, A, Weinreb, M, (2001). Systemic prostaglandin E2 increases cancellous bone formation and mass in aging rats and stimulates their bone marrow osteogenic capacity in vivo and in vitro . - : J Endocrinol


   


Archive Article

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Volume : 44 / No. : 1 / Pub. : 2008-01
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  4. Difference of interferon gammalevel (release assay) in nurses exposed to mycobacterium tuberculosis and active tuberculous patients
  5. Molecular expression of estrogen receptor alpha (erα) and interleukin 6 (il-6) on acceleration of healing process of long bone shaft fracture by immediate repetitive axial compression tension stabilization (ireact)
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  11. Bone morphogenetic protein 4 (bmp4) and prostaglandin alpha (pge2α) molecular expression in healing process acceleration of long bone shaft fracture using immediate repetitive axial compression tension stabilization (ireact)
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