Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 4 / Published : 2008-10

Order : 4, and page :242 - 250

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Original Article :

Cell surface her2/neu oncoprotein expression in breast ductal carcinoma

Author :

  1. Imam Susilo*1
  1. Department of Anatomic Pathology, Airlangga University School of Medicine, Dr Soetomo Teaching Hospital, Surabaya

Abstract :

Breast cancer is a malignant tumor mostly disclosed in women. It has heterogeneous biological behavior - so that the knowledge of tumor markers is very important to determine its prognosis and therapy. Up to now, the determination of prognosis and treatment of choice is still based on clinical and morphologic finding although recent studies pointed out that there was tight relationship between carcinoma growth and molecular abnormalities including normal cell gene consisting of proto-oncogene, tumor suppressor gene, programmed cell death and DNA repair gene. Therefore, the description of molecular changes is required - in determining the prognosis and therapy of breast cancer. Molecular pathologic approach may offer a prospective promise even though the genetic mechanism of molecular carcinogenesis of breast cancer is still unclear. In this study, immunopathologic investigation was carried out by using immunohistochemical method, with antibody monoclonal against protein HER2/neu. Based on multivariate test of Wilks' Lambda method, protein expression of HER2/neu was concomitantly different in various tumor diameters of breast cancer (p = 0.000 < a = 0.05). With method of Wilks' Lambda method, protein expression HER2/neu was simultaneously different in various carcinoma cell differentiation of breast cancer (p = 0,000 < a = 0.05) and with Wilks' Lambda method, protein expression HER2/neu, was concomitantly different in various progressiveness of ductal carcinoma growth (p= 0,000 < a = 0.05). Also with Wilks' Lambda method, protein expression HER2/neu was concomitantly different in various grade of ductal carcinoma (p = 0.000 < a = 0.05). It showed that cancer of the breast occurred in genetic lesion.

Keyword :

Ductal carcinoma of the breast, prognosis, molecular pathological role,

References :

Kumar V, Abbas, AK., Fausto, N,(2005) Robbin and Cotran Pathologic Basis of Disease, 7th. Ed Philadelphia : WB Sounders

Rosai, J,(1996) Ackerman's Surgical Pathology, 8th edn St. Louis : Mosby-Year Book, Inc.

Tavassoli, FA, Devilee, P,(2003) World Health Organization Classification of Tumours, Pathology and Genetics of Tumours of the Breast and Female Genital Organs Lyon : IARC Press

Archive Article

Cover Media Content

Volume : 44 / No. : 4 / Pub. : 2008-10
  1. Genetic Variation Of G6pd And Adaptive Phenomena In Malarial Infection
  2. Molecular Analysis Of The Coding Sequence Of Mage-1 Gene From Hepatocelular Carcinoma Patient And Testis
  3. Potential Value Of C-reactive Protein As Inflammation Marker And Il-1β, Tnf- As Pro-inflammatory Cytokine On Disease Activity Of Rheumatoid Arthritis
  4. Cell Surface Her2/neu Oncoprotein Expression In Breast Ductal Carcinoma
  5. Difference In The Productivity Of B-lymphocyte Isolated From Lymph Nodes And That Isolated From Mice Spleen In The Production Of Toxocara Cati Monoclonal Antibody Using Hybridoma Technology
  6. Exploration In The Use Of Medicinal Plant Acanthus Ilicifolius L In The Treatment Of Endothelial Dysfunction
  7. Detection Of M. Tuberculosis And Drug Sensitivity Test From Sputum Culture Of Pulmonary Tuberculosis Patients In Dr Soetomo General Hospital Between 2003-2004
  8. The Pharmacokenetics Of Levofloxacin In Healthy Rabbit Treated With Antacid
  9. Potency Of Lactobacillus Reuteri On Reduced Inflammation In Septic Encephalopathy
  10. Pharmacokinetic Parameters Determination Of A Single 500-mg Oral Dose Of Levofloxacin In Healthy Subjects By Using Blood Data
  11. Encephalopathy And Neuroendocrine Disorder In Septic Shock
  12. Osteoarthritic Pain Treatment With Electroacupuncture
  13. Review Article And Clinical Experience: Astaxanthin – Oxidative Stress – Diabetes Mellitus From Basics To Clinics And From General To Specific