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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 41 / No. 3 / Published : 2005-07

TOC : 8, and page :217 - 221

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Original Article :

Clinical outcome of asthma with house dust immunotherapy in children

Author :

  1. Ariyanto Harsono *1
  2. Irene Ratridewi*2
  1. Department of Child Health Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya
  2. Department of Child Health Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya

Abstract :

Background: Asthma is a chronic inflammatory disease characterized by increased infiltration of variousinflammatory cells into airway. Several previous studies showed specific immunotherapy improved clinical features of asthma due to aeroallergens. Objective: To describe the efficacy of house dust immunotherapy in childhood asthma with house dust allergy. Methods: The asthmatic patients were collected from January to December 2003, from medical records of Allergy Clinic Outpatient's Department, Dr Soetomo Hospital, Surabaya. The allergy skin testing was done to all patients. Patients who suffered from asthma with or without other symptoms (Allergic rhinitis, atopic dermatitis, urticaria) positive house dust allergy were enrolled in this study. Patients with food allergy were controlled with elimination diet, and immunotherapy with house dust extract was given to all patients. The symptoms at the first visit and late 3 months of 1 year immunotherapy were recorded. Data were analyzed descriptively. Results: There were 213 patients came to Allergy outpatient clinic during 2003, 90 (42%) suffered from asthma, 41 (46%) of them received immunotherapy, 41 (46%) did not receive immunotherapy, and 5 (24%) discontinued immunotherapy. Twenty seven (66%) of those received immunotherapy showed no symptom of asthma and other allergy manifestation after one year of treatment, 10 (24%) showed no asthma attack, but other symptoms still occurred infrequently, 4 (10%) showed asthma attack and other symptoms. Conclusion: Immunotherapy results in clinical improvement among 90% of asthmatic children with house dust allergy, and should be suggested in the management of childhood asthma with house dust allergy. It seems that immunotherapy also results in the decrease of other symptoms related with allergy.

Keyword :

asthma, house dust, allergy, immunotherapy, outcome,


References :

  1. Abba IT, (2003). Allergy desensitization. In: Mardiney MR. Immunology. 3rd edition . New York : Marcel Dekker
  2. Bradding P, Walls AF, Church MK, (1995). Mast cells and basophiles: their role in initiating and maintaining inflammatory responses. In: Holgate ST, ed. Immunopharmacology of the Respiratory System . London : Academic Press


   


Archive Article

Cover Media Content

Volume : 41 / No. : 3 / Pub. : 2005-07
  1. Editorial vol 41 no 3 2005
  2. Opinion: the dramatic avian influenza epidemic and the pig connection
  3. The potency of piperine as antiinflammatory and analgesic in rats and mice
  4. Brain derived neurotrophic factor (bdnf) is a key mediator of learning plasticity
  5. Migraine headache in a child with house dust and mite allergy. a case report
  6. Long versus standard initial steroid therapy for children with idiopathic nephrotic syndrome
  7. Research article: the effect of nursing care approach model (ncam = pakar) on the increase of cd4 cell count for patient with hiv infection
  8. Clinical outcome of asthma with house dust immunotherapy in children
  9. Different clinical manifestation of cerebral lupus due to different brain involvement. a report of two cases
  10. A comparative test of eyedrops timolol 0.5% and betaxolol 0.5% in the reduction of intraocular pressure in primary open-angle glaucoma in dr soetomo hospital, surabaya
  11. Efficacy of fine needle biopsy in the diagnosis of tuberculous cervical lymphadenitis
  12. Molecular and immunological aspects of anemia in malaria
  13. Review article and clinical experience: insulin glargine combined with oral agent in t2dm (clinical uses of formulas: 1/3, 5-5, 2-2, 1-1, and 1-2)