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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 46 / No. 4 / Published : 2010-10

TOC : 2, and page :241 - 246

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Original Article :

Combination of metformin and hyperbaric oxygen therapy increased enos concentration

Author :

  1. Bernadette Dian Novita Dewi*1
  2. Endang Isbandiati*2
  3. Guritno*3
  1. Division of Post Graduated Program of Pharmacology and Therapeutic, Department of Pharmacology, Faculty of Medicine, University of Airlangga, Surabaya Indonesia
  2. Division of Post Graduated Program of Pharmacology and Therapeutic, Department of Pharmacology, Faculty of Medicine, University of Airlangga, Surabaya Indonesia
  3. Division of Post Graduated Program of Hyperbaric Medicine, Department of Physiology, Faculty of Medicine, University of Airlangga, Surabaya Indonesia

Abstract :

Metformin is the first line drug of type 2 diabetes patients. Its improves Insulin sensitivity as mechanism of action via activation of adenomonophosphate activated protein kinase (AMPK), reduces hepatic glucose product, and increases endothelial Nitric Oxide Synthase (eNOS). Chronic hyperglycemia induces Nitric Oxide (NO) dysfunction, whereas, NO is important vasodilator in human body. Due to of NO dysfunction, cells become hypoxia to ischemic then cell apoptotic, included cells beta pancreatic. This study aim to find new management in optimalisation of Metformin therapy in patients with type 2 diabetes, especially in the improvement of blood glucose into ’normoglycemia’ and eNOS. Hyperbaric oxygen (HBO) therapy, 2.4 ATA oxygen, which is given 3x30 minutes with 5 minutes intervals with air for 10 times within 10 days continually, reduces directly blood glucose, improves NO function and inhibits cytokines released. Therefore, HBO therapy is considered as an adjuvant treatment in type 2 DM beside Metformin. This study was conducted by a clinical pre and post experiment without control. The ten men’s correspondents in the study were chosen randomly. Blood glucose and eNOS concentration were examined before, during and after the combination treatment of Metformin and HBO therapy were given. The concentration of eNOS was increased significantly and blood glucose reduced significantly after the combination treatment of Metformin and HBO therapy. In conclusion, HBO therapy works synergism with Metformin in diabetes type2 therapy, especially by improving Metformin therapy in reduced blood glucose and raised eNOS.

Keyword :

type 2 diabetes, metformin, HBO, eNOS , blood glucose,


References :

  1. Coleman JW, (2001). Nitric oxide in immunity and inflammation. - : Int Immunopharmacol
  2. Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM, (2009). Pharmacotherapy : A Pathophysiologic Approach, 7th ed. New York : McGraw Hill Companies, Inc
  3. Goodman and Gilman A, (2006). The Pharmacological Basis of Therapeutics, 11th ed. New York : The Mc Graw-Hill Companies, Inc.


   


Archive Article

Cover Media Content

Volume : 46 / No. : 4 / Pub. : 2010-10
  1. Contribution of lifestyle and obesity to the incidence of pre-diabetes
  2. The importance of parenting on growth and development in toddlers
  3. Combination of metformin and hyperbaric oxygen therapy increased enos concentration
  4. Description of blood viscosity from diabetes mellitus outpatients in endocrine clinic, aw sjahranie hospital, 2009
  5. 2-methoxyethanol exposure affects protein profile of testicular sperm membrane in mice (mus musculus)
  6. Extract of psidium guajava leaves reduces malondialdehyde in soleus muscle of wistar rats directly after acute physical activity
  7. Occupational health and safety behavior analysis and nosocomial infection risk in cleaning service workers at dr. seotomo hospital surabaya
  8. Groundstroke exercise combined with jogging can increase the physical fitness of tennis players
  9. Hematocrite as a screening test of iron deficiency occurrence in tetralogy of fallot
  10. Comparison of maternal zinc level in term pregnancy associated with premature rupture of membranes in normal pregnancy
  11. Predominance of right hemisphere in post-ischemic stroke immunity modulation
  12. Screening in proteinuria-hematuria among 5 - 26 years old students in closed community school in surabaya, indonesia
  13. Non-specific pattern of ultrasonogram (usg) in lymphoma of the breast
  14. Hormonal status (estrogen receptors - progesterone) and her-2 neu in various cyclin d1 expressions in breast cancer