UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 3 / Published : 2014-07

Order : 10, and page :187 - 190

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Original Article :

Comparative effectiveness of paracetamol and metamizol as antipyretics in patients with moderate and severe brain injury in dr. soetomo hospital, surabaya

Author :

  1. Nasruhan A*1
  2. Suharjono*2
  3. Joni Wahyuhadi*3
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Patients with moderate and severe brain injury have increased recently. They were having a lot of complications namely seizures,hyperthermia, pain and several other complications. One of the most common complication in patients with moderate and severebrain injury is acute hyperthermia. Acetaminophen or Metamizole is often used for this case. The study of this clinical observation isto compare the effectiveness of Acetaminophen and Metamizole as an antipyretic in patients with moderate and severe brain injuriesin Dr. Soetomo hospital. The population of this study was patients with moderate and severe brain injuries in SMF neurosurgeryward in Dr. Soetomo hospital who obtained paracetamol and metamizol as the therapy. The study was taken from January to April2013. We studied 32 patients who had febrile episode, 8 patients with moderate brain injury and 8 patients with severe brain injuryreceived acetaminophen, 8 patients with moderate brain injury and 8 patients with severe brain injury who received metamizole byaxilla examination. Patient's temperature was measured before and 15, 30 minute, 1, 2, 3, 4, 5, 6 hours after drug infusion. Thisstudy demonstrates the effectiveness of acetaminophen and metamizole as an antipyretic in moderate brain injury were notsignificantly different (p = 0.583). The Effectiveness of acetaminophen and metamizole as antipyretic in severe brain injury does nothave a significant difference (p = 0.651). Acetaminophen and metamizol have the same antipyretic activity in moderate and severebrain injury in Dr.Soetomo hospital Surabaya. (FMI 2014;50:187-190)

Keyword :

acetaminophen, metamizole, antipyretic, brain injury, neurosurgery,


References :

Thompson HJ, Tkacs NC, Saatman KE, Raghupathi R, McIntosh TK,(2003) Hyperthermia following traumatic brain injury: a critical evaluation 12, 163-173 : Neurobiol Dis

Vera P, Zapata L, Gich I, Mancebo J, Betbesé AJ,(2012) Hemodynamic and antipyretic effects of paracetamol, metamizol and dexketoprofen in critical patients 36, 619-625 : Medicina Intensiva





Archive Article

Cover Media Content

Volume : 50 / No. : 3 / Pub. : 2014-07
  1. Heavy Metal Contamination May Have A Role In Negative Correlation Between Seafood Consumption And Visuo-motor Development Of 1-3 Year-old Children In Subdistrict Bulak, Surabaya
  2. Detection Of Gyra Gene Mutation Region In Fluoroquinolone Resistant Mycobacterium Tuberculosis Isolate From Surabaya Indonesia
  3. Intravenous Vitamin C Administration Decreases Nitric Oxide Serum Level In Severe Burn Injury
  4. The Overview Of Macrophage, Mast Cell, And Lymphocyte Activity In The Efficacy Distinction Of Pain Reduction For Dry And Wet Cupping Therapies
  5. Effectiveness Of Fosfomycin On Prevention Of Surgical Site Infection Of Closed Brain Injury Patients After Craniotomy In Emergency Unit Dr. Soetomo Hospital
  6. Soot Particulate Matter Exposure Increases Interleukin 6 Levels In The Mechanism Of Cardiovascular Disorders
  7. Electric Shock Increases Vcam And Mcp In Mice Endothelial Blood Vessel
  8. Magnesium And Potassium Parenteral Supplementation Does Not Produce Significant Effect On Magnesium And Potassium Serum Level Of Cervical Cancer Patients Receiving Cisplatin Chemotherapy
  9. Effect Of G-csf On Anc Level In All (acute Lymphoblastic Leukemia) Patient With Neutropenia And Febrile Neutropenia During Chemotherapy
  10. Comparative Effectiveness Of Paracetamol And Metamizol As Antipyretics In Patients With Moderate And Severe Brain Injury In Dr. Soetomo Hospital, Surabaya
  11. Analysis Of Complicated Factors Affecting Therapy Effectiveness In Urinary Tract Infections
  12. In Infant With Acute Diarrhea, Nutritional Status Has Correlation With Dehydration Degree, But Not With Mother’s Education And Breastfeeding
  13. The Use Of Antibiotics In Patients With Urinary Tract Infection

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