UNIVERSITAS AIRLANGGA



Detail Article

Berkala Ilmiah Kimia Farmasi

ISSN 2302-8270

Vol. 1 / No. 1 / Published : 2012-11

Related with : Scholar   Yahoo!   Bing

Original Article :

Potensi antijamur isolat streptomyces spp. dari tanah kompos rkbs terhadap trichophyton mentagrophytes

Author :

  1. Mega Ferdina Warsito*1
  2. A. Toto Poernomo*2
  3. Noor Erma NS.*3
  1. -
  2. Departemen Kimia Farmasi, Fakultas Farmasi Universitas Airlangga
  3. Departemen Kimia Farmasi, Fakultas Farmasi Universitas Airlangga

Abstract :

Trichophyton mentagrophytes has been widely recognized to be resistant to certain antifungal drugs.  Yulistyani et al. (2010) successfuly isolated six isolates of Streptomyces sp. from RKBS which has proven to have antifungal potency against Candida albicans. The potency of those isolates was examined against T. mentagrophytes.   This study was aimed to investigate the antifungal potency of Streptomyces spp. against T. mentagrophytes. Screening method using hole diffusion was employed to reveal whether the isolates could have such antifungal potency. The most active isolate was further observed to figure out the antifungal production profile and the growth profile of Streptomyces in 24 hours period for 12 days. The fermentation was done in ISP-4 medium (pH 7,2  ± 0,2, 150 rpm, and 34,0 ± 1,0 °C). The growth of Streptomyces was measured by dry cell weight method. Based on the screening result, the Streptomyces sp. C, Ep, and F show antifungal potency against T. mentagrophytes which were expressed as inhibition zone. Streptomyces sp. Ep has the highest antifungal potency. It is also find that the antifungal potency of Streptomyces sp. Ep reaches its peak of antifungal production in the fourth day of fermentation. The potency of Streptomyces sp. Ep against T. mentagrophytes was determined by three level dose method using ketoconazole as reference drug. The antifungal potency of 100 µl Streptomyces sp. Ep suspension is equivalent to 8.325 ppm ketoconazole.

Keyword :

Streptomyces, Trichophyton mentagrophytes, antifungal, ketoconazole, compost,


References :

Yulistyani, I,(2010) Pemberdayaan Tanah Rumah Kompos Bratang Surabaya sebagai Sumber Streptomyces sp. Penghasil Antibiotik Jakarta : Direktorat Penelitian dan Pengabdian kepada Masyarakat Direktorat Jenderal Pendidikan Tinggi

Venkatesan, G,(2007) Trichophyton rubrum – the predominant etiological agent in human dermatophytoses in Chennai, India India : Afr J Microbiol Res Vol. 1 No.1

Vandamme, E. J.,(1984) Biotechnology of Industrial Antibiotics New York : Marcel Dekker, Inc.





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2012-11
  1. Upaya Peningkatan Kualitas Minyak Kelapa Yang Dibuat Dari Cocos Nucifera L Dengan Berbagai Metode Kimiawi Dan Fisik
  2. Potensi Antijamur Isolat Streptomyces Spp. Dari Tanah Kompos Rkbs Terhadap Trichophyton Mentagrophytes
  3. Pembuatan Dan Karakterisasi Elektrode Selektif Ion (esi) Salbutamol Berbasis Membran Tipe Kawat Terlapis
  4. Validasi Metode Penetapan Kadar Deltametrin Dalam Kubis (brassica Oleracea Var. Capitata) Menggunakan Kromatografi Gas Dengan Detektor Ionisasi Nyala
  5. Optimasi Metode Ekstraksi Untuk Analisis Triadimefon Pada Kubis Secara Kromatografi Gas-spektrometri Massa
  6. Validasi Metode Kromatografi Gas-spektrometri Massa Untuk Analisis Residu Pestisida Triadimefon Dalam Kubis
  7. Optimasi Preparasi Sampel Untuk Analisis Deltametrin Dalam Kubis (brassica Oleracea Var. Capitata)

Information FMI@comparison-of-apoptotic-index-and-the-amount-of-brain/BIKF