UNIVERSITAS AIRLANGGA



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Jurnal Farmasi dan Ilmu Kefarmasian

ISSN

Vol. 1 / No. 1 / Published : 2014-01

Order : 6, and page :28 - 30

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Original Article :

Penentuan dosis asam p-metoksisinamat (apms) sebagai antiinflamasi topikal dan studi penetrasi apms melalui kulit tikus dengan dan tanpa stratum korneum

Author :

  1. Widji Soeratri*1
  2. Tristiana Erawati*2
  3. Diny Rahmatika*3
  4. Noorma Rosita*4
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Mahasiswa Fakultas Farmasi
  4. Dosen Fakultas Farmasi

Abstract :

The aims of researchs to measure para methoxy cinnamic acid (PMCA) dose and the effect of stratum corneum on its penetration parameter. Para methoxy cinnamic acid dose was observe by comparing with diclofenac sodium 1% on decreassing oedema of hind paw Wistar rat that had been induced with 1% caragenan suspension. On the penetration of PMCA study was performed by use of fullthick rat skin membrane and its without stratum corneum, in undersaturated PMCA concentration. Result of the study showed that PMCA exhibited antiinflamation topical effect 0.64 fold of  1% diklofenac sodium in the same route.  Based on molarity equivalence calculation with diklofenac sodium, PMCA dose as antiinflamation topical was 8.7%.  Regarding the PMCA penetration test had been concluded that there was a significant different statistically between flux of PMCA through fullthick rat skin membrane and none. Permeability of skin without stratum corneum was higher than the fullthick rat skin.   Keywords: Para methoxy cinnamic acid (PMCA), antiinflamation topical dose, penetration 

Keyword :

Para methoxy cinnamic acid (PMCA), antiinflamation topical dose, penetration,


References :

Ansel HC,(1989) Pengantar Bentuk Sediaan Farmasi Jakarta : UI-Press

Erawati T, Soeratri W, Hendradi E, Poerwanti T, Rosita N,(2011) Uji efektivitas asam para metoksisinamat sistem solid lipid nanopartikel dalam basis gel. Laporan penelitian Project grant Surabaya : Fakultas Farmasi Unair

Ganiswara SG,(1995) Farmakologi dan Terapi. Edisi ke-4, Fakultas Kedokteran Universitas Indonesia Jakarta : Gaya Baru

Katzung BG,(2007) Farmakologi Dasar dan Klinik. 10th ed Jakarta : Salemba Medika

Sadono, Hasmono D,(2000) Ketersediaan Hayati/ Profil Farmakokinetik Kristal APMS (Isolat Bahan Aktif Serbuk Rimpang Kencur) pada Hewan Coba Kelinci Surabaya : Laporan Penelitian, Lemlit UNAIR





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2014-06
  1. Pemberian Informasi Lama Terapi Dan Konfirmasi Informasi Obat Perlu Ditingkatkan Di Puskesmas
  2. Uji Aktivitas Antimalaria Ekstrak Air Daun Johar (cassia Siamea Lamk) Terhadap Plasmodium Berghei Secara In Vivo
  3. Pelepasan Gentamisin Dari Pelet Bovine-hydroxyapatite-gelatin Sebagai Sistem Penghantaran Obat Dan Pengisi Tulang
  4. Aktivitas Antiviral Batang Eucalyptus Globulus Terhadap Virus Hepatitis C Jfh1a
  5. Sintesis Khalkon Dan Derivatnya Menurut Reaksi Kondensasi Claisen Schmidt Dengan Iradiasi Gelombang Mikro
  6. Penentuan Dosis Asam P-metoksisinamat (apms) Sebagai Antiinflamasi Topikal Dan Studi Penetrasi Apms Melalui Kulit Tikus Dengan Dan Tanpa Stratum Korneum
  7. Studi Kelarutan Dan Disolusi Kompleks Inklusi Ketoprofen-hidroksipropil -siklodekstrin (dibuat Dengan Metode Kopresipitasi)

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