UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Ners

ISSN 1858-3598

Vol. 9 / No. 1 / Published : 2014-04

Order : 5, and page :26 - 34

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Original Article :

The effect of orlistat, green coffee bean extract, and its combinations on lipid profile and adiponectin levels

Author :

  1. Joko Setyono*1
  2. Dwi Adi Nugroho*2
  3. Mustofa*3
  4. Saryono*4
  1. Fakultas Kedokteran dan Imu Kesehatan, Universitas Jenderal Soedirman
  2. Fakultas Kedokteran dan Imu Kesehatan, Universitas Jenderal Soedirman
  3. Fakultas Kedokteran dan Imu Kesehatan, Universitas Jenderal Soedirman
  4. Fakultas Kedokteran dan Imu Kesehatan, Universitas Jenderal Soedirman

Abstract :

Introduction: Obesity prevalence is estimated increases with age, urbanization, economic change, diet, and lifestyle . The prevalence of obesity in Indonesia reached 19.1% of the population aged 15 years and over. This study aimed to determine the differences  of the anti- obesity effect of orlistat, an extract of green coffee beans (Coffea canephora robusta), and its combination to the  adiponectin levels and lipid profile. Method: This research was true experimental post -test only with control group design with completely randomized design (CRD). Experimental animals (Rattus novergicus) were divided  into 6 group, group 1 ( negative control ), group 2 ( positive control ), group 3 was group of obese rats fed orlistat dose of 15.9 mg/kg, group 4 was the group of obese rats were fed ethanol extract of green coffee beans dose of 400 mg/kg, group 5 was the group of obese rats were given water extract of green coffee beans dose of 400 mg/kg, and group 6 was group of obese rats were fed a combination of orlistat dose of 15.9 mg/kg and ethanol extract of green coffee beans at a dose of 400 mg/kg. Lipid profiles and adiponectin levels were measured with a spectrophotometer at 500nm absorbance. The data were analyzed by one-way ANOVA, and then post hoc Least Significant Difference (LSD). Statistical test performed with a level of 95 % (α = 0.05). Result: Ethanol extract of green coffee is more efficient in lowering LDL cholesterol, increasing HDL cholesterol, and lowering the total cholesterol levels on HFD diet-induced mice, but there was no difference in lowering triglycerides . The combination of ethanol extract of green coffee with orlistat showedthe increasing of adiponectin levels were highest than the other treatment groups. Discussion: Compared to the other treatment groups, the ethanol extract of green coffee readily diffuses through the digestive tract epithelium. Green coffee contains chlorogenic acid active compounds that can increase the body's metabolism, increase fatty acid oxidation, reduce levels of triglycerides in the liver, and working to inhibit lipase and amylase pancreaticenzymes. In addition to chlorogenic acid, polyphenol content in coffee is also potentially reduce visceral fat accumulation. Therefore, the ethanol extract of green coffee can lowering LDL and total cholesterol and increasing HDL significantly compared to the other treatment groups. Preparations extract by ethanol allows the absorption process is done efficiently and quickly.

Keyword :

obesity, orlistat, greencoffee, lipid profile, adiponectin,


References :

Vassallo, J.,(2007) Pathogenesis of Obesity - : Journal of the Malta College of Pharmacy Practice, 12: 19-22

World Health Organization (WHO),(2013) Obesity and Overwight - : www.who.int





Archive Article

Cover Media Content

Volume : 9 / No. : 1 / Pub. : 2014-04
  1. The Impact Of Green Tea On Blood Fluidity Improvement And Weight Loss
  2. Sense Of Coherence On Liquor Abuse Among Teenagers In Salutogenesis Context
  3. Nurses` Knowledge, Attitudes, And Practices Of Universal Precaution Toward Hiv/aids Transmission
  4. Bedside Teaching: Is It Effective Methods In Clinical Nursing Students Learning?
  5. The Effect Of Orlistat, Green Coffee Bean Extract, And Its Combinations On Lipid Profile And Adiponectin Levels
  6. The Importance Of Hair And Scalp Hygiene For Pediculus Humanus Capitis Epidemic Prevention
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