UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Penelitian Medika Eksakta

ISSN 1411-6626

Vol. 7 / No. 1 / Published : 2008-04

Related with : Scholar   Yahoo!   Bing

Original Article :

Modifikasi pati singkong pregelatin sebagai bahan pembawa cetak langsung

Author :

  1. Helmy Yusuf*1
  2. Achmad Radjaram*2
  3. Dwi Setyawan*3
  1. Fakultas Farmasi Universitas Airlangga
  2. Fakultas Farmasi Universitas Airlangga
  3. Fakultas Farmasi Universitas Airlangga

Abstract :

The influence of L-HPC LH 11 in Pregelatin Cassava starch as a coprocess material have been investigated to create a new tablet excipient. The suspension of Pregelatin Cassava starch was prepared in condition 55°C for 70 minutes. The length of the heating time was determined by optimising upon sol iod reaction. The colour intensity was measured by spectrophotometer UV-Vis. The concentrations of L-HPC LH 11 were 0% (PP1), 5% (PP2) and 10% (PP3) respectively. Particles reduction was using oscillating granulator with speed of 20 rpm mesh 28. X-Ray diffraction showed declining of crystalline peak of pregelatin cassava starch. Physical characteristics of Granules has also been determined to know whether it has fulfilled the standard requirements or not to produce good tablets. The tests consist of moisture content (MC) test, particle size determination, fluidity, repose angle, appearance and taped density and compressibility. The MC test result is 9,81% - 10,28%. The percentage of fines particle are 5,10% (PP1); 14,10% (PP2) and 27,90% (PP3) respectively. For fluidity test, the results are 14,63 g/s (PP1); 8,86% g/s (PP2) and 10,29% (PP3). Repose angle results are 29,27 (PP1); 31,76 (PP2) and 30,93 (PP3). For compressibility test, the results are 11,48% (PP1); 16,33% (PP2) and 22,30% (PP3). In addition, compactibility test showed that the more higher the percentage of L-HPC LH 11, the harder the tablets produced. The dilution potency test which was using parasetamol as drug model, showed that the tablet hardness reduced with the higher concentration of parasetamol. But, the friability was increased with the higher concentration of parasetamol, and from the experiment, it can be concluded that the vehicle could load parasetamol up to 30%.

Keyword :

Cassava starch, pregelatin, modification, direct compression,


References :





Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2008-04
  1. Efek Pemberian Epinefrin Terhadap Hemoglobin, Jumlah Eritrosit Dan Retikulosit
  2. Perubahan Oral Flora Dan Sensitifitas Karies Gigi Anak Setelah Pengulasan Fluoride Secara Topikal
  3. Potensi Analgesik Dan Antiinflamasi Dari Ekstrak Tapak Liman (elephantophus Scraber)
  4. Efek Antinociceptif Gaba Agonis Gabapentin Terhadap Nyeri Neuropati Pada Hewan Coba Mencit
  5. Modifikasi Pati Singkong Pregelatin Sebagai Bahan Pembawa Cetak Langsung
  6. Efek Sitotoksik In Vitro Dari Ekstrak Buah Mahkota Dewa (phaleria Macrocarpa) Terhadap Kultur Sel Kanker Mieloma
  7. Pemberian Whole Serum Kuda Lokal Bunting Yang Disentrifugasi Dengan Charcoal Terhadap Birahi Dan Kebuntingan Pada Sapi Potong
  8. Inferensi Kurva Regresi Nonparametrik Berdasarkan Estimator Polinomial Lokal Dengan Error Lognormal
  9. Faktor-faktor Yang Mempengaruhi Perempuan Dalam Menghadapi Menopause
  10. Manipulasi Reproduksi Pada Itik Petelur Afkir Dengan Pregnant Mare Serum Gonadotropin

Information FMI@comparison-of-apoptotic-index-and-the-amount-of-brain/JPME