UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 9 / No. 1 / Published : 2016-02

Order : 8, and page :43 - 48

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Original Article :

Potency of curcumin on histopathological changes in the liver of pregnant mice intoxicated by cadmium

Author :

  1. Dewita*1
  2. Widjiati*2
  3. Sri Pantja Madyawati*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

Cadmium is one of heavy metal that caused disturbance to kind of organs. Liver is the main target of Cadmium Intoxication. The damage of the liver caused by oxidative stress which cause lipid peroxidation. Lipid peroxidation made changes in the cells that lead to death of the cells or necrosis. The purpose of this study was to know the histopathological changes of liver through the amount of total hepatocytes necrosis. Twenty Mus musculus divided into four different groups. K0 as negative control group, K1 as positive control group which injected by Cadmium 4,5mg/kgBW, K2 as the group that given Curcumin therapy 150mg/kgBW and K3 as the group that given Curcumin therapy 300mg/kgBW. Day 17 all mice were sacrified for histopathological examination. The result of the experiment get through examination of total hepatocytes necrosis from 500 hepatocytes that observed by light microscope with 400x magnification. The data was analyzed by ANOVA and Honestly Significant Difference test (HSD/Tukey). Result showed that the number of hepatocyte necrosis decreased in compliance with the dose of Curcumin administration. The conclusion is Curcumin can decrease the number of cell death and improve the quality of hepar histopatology.

Keyword :

Cadmium, Necrosis, Curcumin, Hepatocyte,


References :

Matovic´, V., Dukic´-C´osic´.D., A. Buha., and Z. Bulat,(2013) Route, Dose and Duration of Exposure to Cadmium-relevance to Oxidative Stress Induction. In: Bogaert, L., Coppens, N. (Eds.), Peroxidases: Biochemical Characteristics, Functions and Potential Applications 159–175 : Nova Science Publishers

Matović, V., A. Buha, D. Dukic´-C´osic and Z. Bulat,(2015) Insight into the Oxidative Stress Induced by Lead and/or Cadmium in blood, Liver and Kidney.Elsevier 78: 130-140 : Food and Chemical Toxicology

Liu, L., R. Tao, J. Huang, X. He, L. Qu, Y. Jin, S. Zhang and Z. Fu.,(2015) Hepatic oxidative stress and inflammatory responses with cadmium exposure in male mice 39: 229-236 : Environmental Toxicology and Pharmacology





Archive Article

Cover Media Content

Volume : 9 / No. : 1 / Pub. : 2016-02
  1. The Effect Of Refrigerator Temperature And Room Temperature On Total Number Of Bacteria In Meat And Skin Broiler
  2. Isolation And Identification Of Campylobacter Sp Of Raw Chicken Meat Satay Sold By Street Satay Vendors
  3. Supplementation Of Insulin Transferrin Selenium On In Vitro Bovine Oocyte Against To Intracelular Calcium Expression
  4. Potency Of Curcumin On Histopathological Changes In The Liver Of Pregnant Mice Intoxicated By Cadmium
  5. Classical Music Mozart Kv 448 Decrease Abnormality Neuroglia Of Mice (mus Musculus) Hippocampus Exposure To Prenatal Stress
  6. The Potency Of Spirulina Platensis Extract In Reducing The Number Of Polymorpho Nuclear Cells In The Skin Incision Wound Of Mice (mus Musculus)
  7. Reproductive Manipulation Of Java Peafowl (pavo Muticus Muticus)

Information FMI@comparison-of-apoptotic-index-and-the-amount-of-brain/VETMED